位于11号染色体长臂23区的常见基因变异rs3802842与中国人群的结直肠癌风险相关。
Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population.
作者信息
Zhang Chunze, Li Xichuan, Zhang Weihua, Wang Yijia, Fan Guanwei, Wang Wenhong, Chen Shuo, Qin Hai, Zhang Xipeng
机构信息
Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, China.
Department of Immunology, Biochemistry and Molecular Biology, 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University, Tianjin 300070, China.
出版信息
Oncotarget. 2017 Jul 31;8(42):72227-72234. doi: 10.18632/oncotarget.19702. eCollection 2017 Sep 22.
A genome-wide association study identified a common genetic variant rs3802842 at 11q23 to be associated with CRC risk with OR=1.1 and = 5.80E-10 in European population. In Chinese population, several genetic association studies have investigated the association between rs3802842 variant and CRC risk. However these studies reported both positive and negative association results. It is still necessary to evaluate a specific variant in a specific population, which would be informative to reveal the disease mechanism. Until recently, there is no a systemic study to evaluate the potential association between rs3802842 and CRC risk in Chinese population by a meta-analysis method. Here, we aim to evaluate this association in Chinese population by a meta-analysis method using 12077 samples including 5816 CRC cases and 6261 controls. We identified the T allele of rs3802842 to be significantly related with an increase CRC risk (=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.
一项全基因组关联研究发现，在欧洲人群中，位于11q23的常见基因变异rs3802842与结直肠癌风险相关，比值比（OR）=1.1，P值=5.80E-10。在中国人群中，已有多项基因关联研究探讨了rs3802842变异与结直肠癌风险之间的关联。然而，这些研究报告的结果既有阳性也有阴性。在特定人群中评估特定变异仍然很有必要，这将有助于揭示疾病机制。直到最近，还没有通过荟萃分析方法对中国人群中rs3802842与结直肠癌风险之间的潜在关联进行系统研究。在此，我们旨在通过荟萃分析方法，利用12077个样本（包括5816例结直肠癌病例和6261例对照）评估中国人群中的这种关联。我们发现，在中国人群中，rs3802842的T等位基因与结直肠癌风险增加显著相关（P=2.22E-05，OR=1.14，95%置信区间为1.07-1.21）。
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