中国汉族人群中基因多态性与IgA肾病风险的关联
Association between gene polymorphisms and IgA nephropathy risk in a Chinese Han population.
作者信息
Yang Xiaohong, Zhang Yin, Li Wenning, Su Yan, Niu Dan, Wang Yanni, Huang Haiyang, Han Hui, Zhang Daofa, Xie Maowei, Su Huiluan, Xu Wentan, Wei Jiali
机构信息
Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China.
Department of Nephrology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
出版信息
Oncotarget. 2017 Aug 1;8(42):72375-72380. doi: 10.18632/oncotarget.19758. eCollection 2017 Sep 22.
Multiple genetic and environmental factors together contribute to the risk of IgA nephropathy (IgAN). play an important role in the recruitment of the exosome to the pre-rRNA. However, to date, little information is found about the association between polymorphisms and the IgAN risk. In this case-control study, we genotyped five single nucleotide polymorphisms (SNPs) in gene in 416 IgAN cases and 495 controls using Sequenom Mass-ARRAY technology and evaluated their association with IgAN using the χ2 and genetic model analysis. In the allelic model analysis, we determined rs1056654 was associated with a 0.774-fold decrease in the risk of IgAN (95%CI= 0.630-0.952; = 0.015). In the genetic model analysis, we found that the "C/C" genotype of rs1056675 was associated with an increased risk of IgAN based on the codominant model (OR =1.48; 95% CI=1.03-2.13; =0.033) and recessive model (OR =1.52; 95% CI=1.11-2.09; =0.0095). The "G/A-A/A" genotype of rs1056654 was associated with a decreased risk of IgAN based on the dominant model (OR =0.75; 95% CI=0.58-0.98; =0.032) and log-additvie model (OR =0.78; 95% CI=0.64-0.96; =0.0188). Our data suggested that gene polymorphisms in the may exert influences IgAN susceptibility in a Chinese Han population.
多种遗传和环境因素共同导致IgA肾病（IgAN）的发病风险。（此处英文原文有误，“play an important role in the recruitment of the exosome to the pre-rRNA.”这句话前面没有主语）然而，迄今为止，关于（此处英文原文有误，前面未提及具体基因，突然说多态性和IgAN风险的关联，指代不明）多态性与IgA肾病风险之间的关联信息甚少。在这项病例对照研究中，我们使用Sequenom Mass-ARRAY技术对416例IgA肾病病例和495例对照的（此处英文原文有误，前面未提及具体基因，突然说基因中的单核苷酸多态性，指代不明）基因中的五个单核苷酸多态性（SNP）进行基因分型，并使用χ2检验和遗传模型分析评估它们与IgA肾病的关联。在等位基因模型分析中，我们确定rs1056654与IgA肾病风险降低0.774倍相关（95%置信区间=0.630 - 0.952；P = 0.015）。在遗传模型分析中，我们发现基于共显性模型（比值比=1.48；95%置信区间=1.03 - 2.13；P = 0.033）和隐性模型（比值比=1.52；95%置信区间=1.11 - 2.09；P = 0.0095），rs1056675的“C/C”基因型与IgA肾病风险增加相关。基于显性模型（比值比=0.75；95%置信区间=0.58 - 0.98；P = 0.032）和对数相加模型（比值比=0.78；95%置信区间=0.64 - 0.96；P = 0.0188），rs1056654的“G/A - A/A”基因型与IgA肾病风险降低相关。我们的数据表明，（此处英文原文有误，前面未提及具体基因，突然说基因多态性对IgAN易感性有影响，指代不明）基因多态性可能对中国汉族人群的IgA肾病易感性产生影响。
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