Wei Linting, Fu Rongguo, Liu Xinghan, Wang Li, Wang Meng, Yu Qiaoling, Tian Tian, Niu Dan, Jin Tianbo, Dai Zhijun, Gao Jie
Department of Nephrology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Kidney Blood Press Res. 2018;43(1):80-87. doi: 10.1159/000486914. Epub 2018 Jan 24.
BACKGROUND/AIMS: Insulin-like growth factor-1 (IGF-1) plays important roles in cellular proliferation, differentiation, and growth. Previous studies showed that single-nucleotide polymorphisms (SNPs) of IGF-1 are associated with various diseases. This case-control study aimed to examine the relationship between IGF-1 polymorphisms and IgA nephropathy (IgAN) risk in a Chinese Han population.
We recruited 351 IgAN patients and 310 healthy controls from Northwestern China. Sequenom MassARRAY was utilized to examine the genotypes of two common IGF-1 SNPs (rs1520220 and rs2195239). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by the Chi square test to evaluate the associations between IGF-1 and IgAN.
Our study demonstrated that IGF-1 gene rs1520220 and rs2195239 polymorphisms did not confer susceptibility to IgAN. We found no correlation between gender, blood pressure, proteinuria, eGFR, and IgAN in both SNPs. However, the rs1520220 and rs2195239 variants were correlated with M1 and E1 in patients with IgAN (M0/M1: CC vs. CG+GG: OR = 1.62, P = 0.04; E0/E1: CC vs. CG+GG: OR = 1.95, P = 0.004; GG vs. GC+CC: OR = 1.90, P = 0.004, respectively).
These results indicate that IGF-1 gene polymorphisms play crucial roles in the histopathological progression of IgAN in the Chinese Han population.
背景/目的：胰岛素样生长因子-1（IGF-1）在细胞增殖、分化和生长中发挥重要作用。先前的研究表明，IGF-1的单核苷酸多态性（SNP）与多种疾病相关。本病例对照研究旨在探讨中国汉族人群中IGF-1多态性与IgA肾病（IgAN）风险之间的关系。
我们从中国西北部招募了351例IgAN患者和310名健康对照。利用Sequenom MassARRAY检测两种常见IGF-1 SNP（rs1520220和rs2195239）的基因型。通过卡方检验计算比值比（OR）和95%置信区间（95%CI），以评估IGF-1与IgAN之间的关联。
我们的研究表明，IGF-1基因rs1520220和rs2195239多态性不会增加IgAN的易感性。我们发现，在这两个SNP中，性别、血压、蛋白尿、估算肾小球滤过率（eGFR）与IgAN之间均无相关性。然而，rs1520220和rs2195239变异与IgAN患者的M1和E1相关（M0/M1：CC与CG+GG比较：OR = 1.62，P = 0.04；E0/E1：CC与CG+GG比较：OR = 1.95，P = 0.004；GG与GC+CC比较：OR分别为1.90，P = 0.004）。
这些结果表明，IGF-1基因多态性在中国汉族人群IgAN的组织病理学进展中起关键作用。
