Wang Chuan, Zhang Xin-Yue, Sun Yu, Hou Xin-Guo, Chen Li
a Department of Endocrinology , Qilu Hospital of Shandong University , Jinan , China.
b Health Management Center , Shandong Provincial Qianfoshan Hospital, Shandong University , Jinan , China.
Gynecol Endocrinol. 2018 Apr;34(4):290-293. doi: 10.1080/09513590.2017.1393065. Epub 2017 Oct 26.
Insulin resistance (IR) has been reported to be highly associated with the pathogenesis of polycystic ovary syndrome (PCOS). Although irisin, a newly identified myokine that may be closely associated with IR, has been implicated in the development of PCOS, the results are still ambiguous. We performed this meta-analysis to compare the circulating irisin levels between PCOS and healthy women and assess the association of irisin with IR. Published works were retrieved from PubMed and Embase databases using combinations of 'irisin' and ('polycystic ovary syndrome' or 'PCOS'). Eight studies involving 1918 PCOS patients and 528 controls were included in the meta-analysis. Publication bias was observed using a funnel plot and Egger's regression asymmetry test. The pooled data indicated that the levels of irisin were at least 45.78 ng/ml [95% confidence interval (CI)] (12.45, 79.12, p = .007) higher in patients with PCOS than that in the healthy controls. Additionally, we did not observe a significant correlation between circulating irisin levels and IR in study populations, although the results may not be reliable for small sample sizes. The current meta-analysis suggested that irisin might contribute to the development of PCOS independent of IR.
据报道，胰岛素抵抗（IR）与多囊卵巢综合征（PCOS）的发病机制高度相关。尽管鸢尾素是一种新发现的可能与IR密切相关的肌动蛋白，已被认为与PCOS的发生有关，但其结果仍不明确。我们进行了这项荟萃分析，以比较PCOS患者和健康女性的循环鸢尾素水平，并评估鸢尾素与IR的关联。使用“鸢尾素”和（“多囊卵巢综合征”或“PCOS”）的组合从PubMed和Embase数据库中检索已发表的研究。荟萃分析纳入了八项研究，涉及1918例PCOS患者和528例对照。使用漏斗图和Egger回归不对称检验观察发表偏倚。汇总数据表明，PCOS患者的鸢尾素水平比健康对照至少高45.78 ng/ml [95%置信区间（CI）]（12.45，79.12，p = 0.007）。此外，我们在研究人群中未观察到循环鸢尾素水平与IR之间存在显著相关性，尽管对于小样本量结果可能不可靠。当前的荟萃分析表明，鸢尾素可能独立于IR促进PCOS的发生。
