Bostancı M S, Akdemir N, Cinemre B, Cevrioglu A S, Özden S, Ünal O
Department of Obstetrics and Gynecology, Sakarya University Faculty of Medicine Research a nd Education Hospital, Sakarya, Turkey.
Eur Rev Med Pharmacol Sci. 2015 Dec;19(23):4462-8.
Polycystic ovary syndrome (PCOS) is clinically heterogeneous endocrine disorders. Insulin resistance-related proteins play a role in the etiopathogenesis of PCOS. Irisin is a newly identified myokine which act like adipokines. Irisin has been shown to be associated with the insulin resistance and metabolic syndrome. The purpose of this study was to determine the serum levels of irisin in PCOS patients and evaluate the correlations with other metabolic and hormonal parameters.
Thirty-five PCOS patients and 35 matched healthy controls were enrolled to study. Serum irisin levels, anthropometric, hormonal and metabolic parameters including HOMA-IR were measured. Linear regression analysis was employed to study the relationship between irisin and hormonal and metabolic parameters.
Serum irisin level in PCOS patients (mean value; 0.491±0.145 µg/mL) was significantly elevated when compared to control group (mean value 0.281±0.138 µg/mL) (p < 0.001). Linear regression analysis showed that serum irisin was positively associated with body mass index, luteinizing hormone, fasting insulin and total cholesterol in the overall patient population but not for PCOS group alone (p < 0.05).
Serum irisin level of PCOS patients was high compared to that of healthy control subjects. In patients with PCOS, this situation may be due to insulin resistance, when there is leptin resistance or metabolic syndrome.
多囊卵巢综合征（PCOS）是一种临床异质性内分泌疾病。胰岛素抵抗相关蛋白在PCOS的发病机制中起作用。鸢尾素是一种新发现的肌动蛋白，其作用类似于脂肪因子。鸢尾素已被证明与胰岛素抵抗和代谢综合征有关。本研究的目的是测定PCOS患者血清鸢尾素水平，并评估其与其他代谢和激素参数的相关性。
招募35例PCOS患者和35例匹配的健康对照者进行研究。测量血清鸢尾素水平、人体测量学、激素和代谢参数，包括HOMA-IR。采用线性回归分析研究鸢尾素与激素和代谢参数之间的关系。
PCOS患者血清鸢尾素水平（平均值；0.491±0.145μg/mL）与对照组（平均值0.281±0.138μg/mL）相比显著升高（p<0.001）。线性回归分析显示，在总体患者人群中，血清鸢尾素与体重指数、黄体生成素、空腹胰岛素和总胆固醇呈正相关，但单独在PCOS组中无相关性（p<0.05）。
与健康对照者相比，PCOS患者血清鸢尾素水平较高。在PCOS患者中，这种情况可能是由于存在胰岛素抵抗、瘦素抵抗或代谢综合征。
