Meurs Kathryn M, Stern Joshua A, Atkins Clarke E, Adin Darcy, Aona Brent, Condit Julia, DeFrancesco Teresa, Reina-Doreste Yamir, Keene Bruce W, Tou Sandy, Ward Jessica, Woodruff Kathleen
Department of Veterinary Clinical Sciences, North Carolina State University, USA.
J Renin Angiotensin Aldosterone Syst. 2017 Oct-Dec;18(4):1470320317737184. doi: 10.1177/1470320317737184.
The objective of this study was to evaluate angiotensin-converting enzyme (ACE) activity in dogs and with and without an ACE polymorphism in the canine ACE gene, before and after treatment with an ACE inhibitor.
Thirty-one dogs (20 wild-type, 11 ACE polymorphism) with heart disease were evaluated with ACE activity measurement and systolic blood pressure before and after administration of an ACE inhibitor (enalapril).
Median pre-treatment ACE activity was significantly lower for ACE polymorphism dogs than for dogs with the wild-type sequence ( P=0.007). After two weeks of an ACE inhibitor, ACE activity was significantly reduced for both genotypes (wild-type, P<0.0001; ACE polymorphism P=0.03); mean post-therapy ACE activity was no different between the groups.
An ACE polymorphism is associated with lower levels of ACE activity. Dogs with the polymorphism still experience suppression of ACE activity in response to an ACE inhibitor. It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor.
本研究的目的是评估犬血管紧张素转换酶（ACE）活性，以及在使用ACE抑制剂治疗前后，犬类ACE基因有无ACE多态性的情况。
对31只患有心脏病的犬（20只野生型，11只ACE多态性）在给予ACE抑制剂（依那普利）前后进行ACE活性测量和收缩压评估。
ACE多态性犬的治疗前ACE活性中位数显著低于野生型序列犬（P = 0.007）。使用ACE抑制剂两周后，两种基因型的ACE活性均显著降低（野生型，P < 0.0001；ACE多态性，P = 0.03）；两组治疗后的平均ACE活性无差异。
ACE多态性与较低的ACE活性水平相关。具有该多态性的犬在使用ACE抑制剂后仍会出现ACE活性受到抑制的情况。犬的基因状态和ACE活性可能会影响具有该变体的犬对ACE抑制剂的反应。
