Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1038 William Moore Drive, Raleigh, NC 27606, USA.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1038 William Moore Drive, Raleigh, NC 27606, USA.
Vet Clin North Am Small Anim Pract. 2023 Nov;53(6):1255-1276. doi: 10.1016/j.cvsm.2023.05.016. Epub 2023 Jul 7.
Cardiomyopathies remain one of the most common inherited cardiac diseases in both human and veterinary patients. To date, well over 100 mutated genes are known to cause cardiomyopathies in humans with only a handful known in cats and dogs. This review highlights the need and use of personalized one-health approaches to cardiovascular case management and advancement in pharmacogenetic-based therapy in veterinary medicine. Personalized medicine holds promise in understanding the molecular basis of disease and ultimately will unlock the next generation of targeted novel pharmaceuticals and aid in the reversal of detrimental effects at a molecular level.
心肌病仍然是人类和兽医患者中最常见的遗传性心脏病之一。迄今为止，已知有 100 多个突变基因可导致人类患上心肌病，而在猫和狗中只有少数几个基因已知。这篇综述强调了在心血管病例管理和兽医药物基于遗传药理学治疗方面采用个性化“一体健康”方法的必要性和用途。个性化医疗有望深入了解疾病的分子基础，并最终解锁下一代靶向新型药物，帮助从分子水平逆转有害影响。
