a Resident of Internal Medicine, Second Department of Internal Medicine , General Hospital of Heraklion 'Venizeleio-Pananeio' , Heraklion , Greece.
b Resident of General Medicine , University Hospital of Heraklion, Voutes , Heraklion , Greece.
Infect Dis (Lond). 2018 Mar;50(3):163-174. doi: 10.1080/23744235.2017.1388537. Epub 2017 Oct 26.
There is a number of publications evaluating the eosinophil count and the neutrophil-to-lymphocyte count ratio for diagnosis, prognosis or monitoring of patients. Of special interest is the use of these parameters for discrimination between the different causes of fever (e.g. bacterial versus viral vs. non-infectious causes of fever) and for monitoring the efficacy of therapy and predict the course of the patient. However, pitfalls in previous study designs prevent applicability to clinical practice. Here, we provide a short review of the relevant literature and summarize important factors that should be taken into account when designing studies, with special attention to the selection of a proper and clinically meaningful study population and the effects of the stress response and of corticosteroids.
有许多出版物评估嗜酸性粒细胞计数和中性粒细胞与淋巴细胞计数比值，用于诊断、预后或监测患者。特别感兴趣的是这些参数用于区分发热的不同原因（例如细菌与病毒与非感染性发热原因）以及监测治疗效果和预测患者病程。然而，先前研究设计中的缺陷妨碍了其在临床实践中的应用。在这里，我们提供了相关文献的简短综述，并总结了在设计研究时应考虑的重要因素，特别关注选择适当且具有临床意义的研究人群以及应激反应和皮质类固醇的影响。
