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嗜酸性粒细胞计数和中性粒细胞-淋巴细胞计数比值作为菌血症患者的预后标志物：一项回顾性队列研究。

Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study.

机构信息

Department of Epidemiology and Health Services Evaluation, Hospital del Mar, Barcelona, España.

出版信息

PLoS One. 2012;7(8):e42860. doi: 10.1371/journal.pone.0042860. Epub 2012 Aug 9.

DOI:10.1371/journal.pone.0042860
PMID:22912753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3415420/
Abstract

INTRODUCTION

There is scarce evidence on the use of eosinophil count as a marker of outcome in patients with infection. The aim of this study was to evaluate whether changes in eosinophil count, as well as the neutrophil-lymphocyte count ratio (NLCR), could be used as clinical markers of outcome in patients with bacteremia.

METHODS

We performed a retrospective study of patients with a first episode of community-acquired or healthcare-related bacteremia during hospital admission between 2004 and 2009. A total of 2,311 patients were included. Cox regression was used to analyze the behaviour of eosinophil count and the NLCR in survivors and non-survivors.

RESULTS

In the adjusted analysis, the main independent risk factor for mortality was persistence of an eosinophil count below 0.0454·10(3)/uL (HR = 4.20; 95% CI 2.66-6.62). An NLCR value >7 was also an independent risk factor but was of lesser importance. The mean eosinophil count in survivors showed a tendency to increase rapidly and to achieve normal values between the second and third day. In these patients, the NLCR was <7 between the second and third day.

CONCLUSION

Both sustained eosinopenia and persistence of an NLCR >7 were independent markers of mortality in patients with bacteremia.

摘要

简介

关于嗜酸性粒细胞计数作为感染患者预后标志物的应用，相关证据较少。本研究旨在评估嗜酸性粒细胞计数的变化以及中性粒细胞-淋巴细胞比值（NLCR）是否可作为菌血症患者临床预后的标志物。

方法

我们对 2004 年至 2009 年住院期间首次发生社区获得性或与医疗保健相关菌血症的患者进行了回顾性研究。共纳入 2311 例患者。采用 Cox 回归分析生存者和非生存者嗜酸性粒细胞计数和 NLCR 的变化。

结果

在调整分析中，死亡率的主要独立危险因素是嗜酸性粒细胞计数持续低于 0.0454·10(3)/uL（HR = 4.20；95% CI 2.66-6.62）。NLCR >7 也是一个独立的危险因素，但重要性较小。幸存者的平均嗜酸性粒细胞计数有迅速升高并在第 2 至第 3 天恢复正常的趋势。在这些患者中，第 2 至第 3 天 NLCR <7。

结论

持续的嗜酸性粒细胞减少和 NLCR >7 持续存在是菌血症患者死亡的独立标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad44/3415420/72561e641f19/pone.0042860.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad44/3415420/9fc96d5cac70/pone.0042860.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad44/3415420/a616b21d55d9/pone.0042860.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad44/3415420/72561e641f19/pone.0042860.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad44/3415420/9fc96d5cac70/pone.0042860.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad44/3415420/a616b21d55d9/pone.0042860.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad44/3415420/72561e641f19/pone.0042860.g003.jpg

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