Department of Anesthesiology and Reanimation, Faculty of Medicine, Zonguldak Bülent Ecevit University Zonguldak, Turkey.
Department of Orthopedics and Traumatology, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.
Medicine (Baltimore). 2024 Oct 25;103(43):e40290. doi: 10.1097/MD.0000000000040290.
Surgical trauma can induce systemic inflammation. The selected anesthesia method may modulate the inflammatory response and surgical results in the inflammatory process that occurs during surgical trauma. In this retrospective study, we aimed to compare the anti-inflammatory effects of general anesthesia and peripheral nerve block (infraclavicular block). Demographic, clinical, and laboratory records (hemogram, total leukocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume) were obtained from the archival data. The patients were divided into 2 groups: Group G, who received general anesthesia, and Group P, who received a peripheral nerve block (infraclavicular block) for forearm surgery. The amount of opioid consumed postoperatively was significantly lower in Group P. Infraclavicular block as an alternative to general anesthesia was found to be associated with a significant decrease in the neutrophil-to-lymphocyte ratio, total leukocyte count, and platelet-to-lymphocyte ratio levels compared to those observed after general anesthesia. Peripheral nerve blocks may play a role in reducing inflammation and alleviating stress.
手术创伤可诱发全身炎症。所选麻醉方法可调节炎症反应，并在手术创伤过程中发生的炎症过程中影响手术结果。在这项回顾性研究中，我们旨在比较全身麻醉和外周神经阻滞（锁骨下神经阻滞）的抗炎作用。从档案数据中获得人口统计学、临床和实验室记录（血象、总白细胞计数、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值和平均血小板体积）。患者分为 2 组：G 组接受全身麻醉，P 组接受前臂手术的外周神经阻滞（锁骨下神经阻滞）。与全身麻醉相比，P 组患者术后阿片类药物的消耗量明显降低。与全身麻醉相比，锁骨下神经阻滞作为全身麻醉的替代方法，与中性粒细胞与淋巴细胞比值、总白细胞计数和血小板与淋巴细胞比值的显著降低有关。外周神经阻滞可能在减轻炎症和应激方面发挥作用。
