奥索地平与硝苯地平对大鼠输精管作用的比较。

A comparison of the effects of oxodipine and nifedipine on rat vas deferens.

作者信息

Martin I, Alfaro M J, Tamargo J

机构信息

Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.

出版信息

J Pharm Pharmacol. 1988 Sep;40(9):657-9. doi: 10.1111/j.2042-7158.1988.tb05332.x.

DOI:10.1111/j.2042-7158.1988.tb05332.x

PMID:2907039

Abstract

The effects of oxodipine, a new dihydropyridine, were studied and compared with those of nifedipine in the complete vasa deferentia and in the prostatic and epididymal halves of the rat vas deferens. Oxodipine and nifedipine, 10(-9) -10(-6)M, produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, noradrenaline (3 x 10(-5)M) and high-K (50 mM). The inhibitory effects of oxodipine were significantly reduced in high Ca media. From these experiments it is concluded that oxodipine, like nifedipine, produced a similar and potent inhibitory effect of the contractile responses induced in the rat vas deferens.

摘要

研究了新型二氢吡啶类药物奥索地平的作用，并将其与硝苯地平在大鼠输精管完整段以及输精管前列腺部和附睾部的作用进行了比较。10(-9)-10(-6)M的奥索地平和硝苯地平对单脉冲刺激、去甲肾上腺素(3×10(-5)M)和高钾(50 mM)诱导的收缩反应产生剂量依赖性抑制。在高钙培养基中，奥索地平的抑制作用显著降低。从这些实验得出结论，奥索地平与硝苯地平一样，对大鼠输精管诱导的收缩反应产生相似且有效的抑制作用。