Liu Chen-Dong, Yang Lu, Pu Hong-Zhou, Yang Qiong, Huang Wen-Yao, Zhao Xue, Zhu Li, Zhang Shun-Hua
1. College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China; 2. Sichuan Tieqilishi Animal Husbandry Science and Technology Limited Company, Mianyang 621000, China.
Agricultural Bureau of Wangcang Sichuan Province, Guangyuan 628200, China.
Yi Chuan. 2017 Oct 20;39(10):888-896. doi: 10.16288/j.yczz.16-364.
As it is well known, proper exercise benefits our mind and body, especially the skeletal muscle. Exercise increases the capacity of muscle metabolism, enhances the biological function of mitochondria, regulates the transformation of muscle fiber types and increases the muscle power. In recent years, more and more researches show that epigenetic regulation plays an important role in strengthening the muscle, and these studies mainly include DNA methylation, histone modification, and regulation of miRNA expression. In order to adapt to the body movement, these three epigenetic patterns change the metabolic capacity of skeletal muscle, mitochondrial biological function and muscle fiber types by regulating the gene expression of skeletal muscle. In this review, we summarize research progresses of exercise-induced epigenetic regulation of gene expression of skeletal muscle, in order to provide a reference for further studies of how sports improve our body health.
众所周知，适当的运动有益于我们的身心，尤其是骨骼肌。运动可提高肌肉代谢能力，增强线粒体的生物学功能，调节肌纤维类型的转变并增加肌肉力量。近年来，越来越多的研究表明，表观遗传调控在增强肌肉方面发挥着重要作用，这些研究主要包括DNA甲基化、组蛋白修饰以及miRNA表达调控。为了适应身体运动，这三种表观遗传模式通过调节骨骼肌的基因表达来改变骨骼肌的代谢能力、线粒体生物学功能和肌纤维类型。在本综述中，我们总结了运动诱导的骨骼肌基因表达表观遗传调控的研究进展，以便为进一步研究运动如何改善我们的身体健康提供参考。
