Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria 3216, Australia.
Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a029876. doi: 10.1101/cshperspect.a029876.
An acute bout of exercise is sufficient to induce changes in skeletal muscle gene expression that are ultimately responsible for the adaptive responses to exercise. Although much research has described the intracellular signaling responses to exercise that are linked to transcriptional regulation, the epigenetic mechanisms involved are only just emerging. This review will provide an overview of epigenetic mechanisms and what is known in the context of exercise. Additionally, we will explore potential interactions between metabolism during exercise and epigenetic regulation, which serves as a framework for potential areas for future research. Finally, we will consider emerging opportunities to pharmacologically manipulate epigenetic regulators and mechanisms to induce aspects of the skeletal muscle exercise adaptive response for therapeutic intervention in various disease states.
急性运动足以引起骨骼肌基因表达的变化，这些变化最终导致对运动的适应性反应。虽然有大量研究描述了与转录调控相关的运动后的细胞内信号转导反应，但涉及的表观遗传机制才刚刚开始显现。这篇综述将概述表观遗传机制以及在运动背景下已知的内容。此外，我们将探讨运动期间代谢与表观遗传调控之间的潜在相互作用，这为未来的研究提供了潜在的研究方向。最后，我们将考虑利用药理学手段来操纵表观遗传调节剂和机制，以诱导骨骼肌运动适应性反应的各个方面，从而在各种疾病状态下进行治疗干预的新机会。
