Ohkubo H, Chiba S
Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
Jpn J Ophthalmol. 1988;32(4):450-6.
The vascular responses to 8 agents, norepinephrine (NE), phenylephrine (PHE), xylazine (XYL), tyramine (TYR), dopamine (DA), 5-hydroxytryptamine (5-HT), prostaglandin F2 alpha (PGF2 alpha) and KCl were examined in human posterior ciliary arteries (HPCAs) which were isolated and perfused with Tyrode's solution gassed with 95% O2 and 5% CO2 under a constant flow rate at 37 degrees C. The rank order for potency of vasoconstrictions was 5-HT greater than NE greater than PHE = PGF2 much greater than DA greater than TYR much greater than KCl. Responses to XYL were various but not significant. DA frequently induced a vasodilatation at smaller doses but a vasoconstriction at larger doses. Although their antagonists were not used in this study, it was suggested that 1) there are rich alpha-1 adrenoceptors and 5-HT receptors, 2) dopaminergic receptors exist in these arteries and 3) there are rich tyramine-sensitive catecholamine stores in nerve terminals.
在人类睫状后动脉（HPCAs）中检测了8种药物（去甲肾上腺素（NE）、去氧肾上腺素（PHE）、赛拉嗪（XYL）、酪胺（TYR）、多巴胺（DA）、5-羟色胺（5-HT）、前列腺素F2α（PGF2α）和氯化钾（KCl））的血管反应。将分离出的HPCAs在37℃下以恒定流速用含95%氧气和5%二氧化碳的台氏液灌注。血管收缩效力的排序为：5-HT＞NE＞PHE = PGF2α＞DA＞TYR＞KCl。对XYL的反应各不相同，但无显著性差异。DA在小剂量时常常引起血管舒张，而在大剂量时引起血管收缩。尽管本研究未使用它们的拮抗剂，但提示：1）存在丰富的α-1肾上腺素能受体和5-HT受体；2）这些动脉中存在多巴胺能受体；3）神经末梢中有丰富的对酪胺敏感的儿茶胺储存。
