Caqueo-Urízar Alejandra, Urzúa Alfonso, Fond Guillaume, Boyer Laurent
Universidad de Tarapacá, Escuela de Psicología y Filosofía, Arica, Chile.
Universidad Católica del Norte, Avda, Angamos, Antofagasta, Chile.
Patient Prefer Adherence. 2017 Oct 6;11:1737-1744. doi: 10.2147/PPA.S144961. eCollection 2017.
The objective of this research was to quantify nonadherence to medication and explore the determinants of nonadherence in patients diagnosed with schizophrenia (SZ) from three countries in Latin America (Bolivia, Peru, and Chile).
This study was conducted in public mental health centers in Bolivia, Peru, and Chile. The data collected included drug attitude inventory (DAI-10), sociodemographic information, and clinical and treatment characteristics of patients with SZ. Multivariate analysis with multiple linear regression was then performed to identify variables that were potentially associated with the DAI score (dependent variable).
Two hundred and fifty-three patients diagnosed with SZ participated in the study and 247 fully completed the DAI-10. In the multivariate analysis, medication nonadherence was associated with being a woman (β=-0.16, =0.029), younger age (β=0.17, =0.020), younger age at onset of disease (β=-0.17, =0.019), and lower insight (β=-0.30, <0.001).
Being a female, younger age, younger age at onset of disease, and lower insight were the main features associated with nonadherence. If future longitudinal studies confirm these findings, these factors should not be neglected in Latin American mental health public policies to address the problem of nonadherence.
本研究的目的是量化精神分裂症（SZ）患者的用药依从性，并探究拉丁美洲三个国家（玻利维亚、秘鲁和智利）中SZ患者用药不依从的决定因素。
本研究在玻利维亚、秘鲁和智利的公共心理健康中心开展。收集的数据包括药物态度量表（DAI-10）、社会人口学信息以及SZ患者的临床和治疗特征。随后进行多元线性回归分析，以确定可能与DAI评分（因变量）相关的变量。
253名被诊断为SZ的患者参与了研究，其中247名患者完整完成了DAI-10量表。在多变量分析中，用药不依从与女性（β=-0.16，P=0.029）、年龄较小（β=0.17，P=0.020）、疾病发病年龄较小（β=-0.17，P=0.019）以及自知力较低（β=-0.30，P<0.001）有关。
女性、年龄较小、疾病发病年龄较小以及自知力较低是与用药不依从相关的主要特征。如果未来的纵向研究证实这些发现，那么在拉丁美洲解决用药不依从问题的心理健康公共政策中，不应忽视这些因素。
