Kassew Tilahun, Demilew Demeke, Birhanu Addis, Wonde Mesele, Liyew Biks, Shumet Shegaye
Department of Psychiatry, University of Gondar, Gondar, Ethiopia.
Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.
Schizophr Res Treatment. 2019 May 22;2019:5094017. doi: 10.1155/2019/5094017. eCollection 2019.
Poor attitude towards antipsychotic drugs is high, and it is a factor for non-adherence to treatment. This increases the risk of relapse, associated healthcare utilization, and costs. This study aimed to assess attitude towards antipsychotic medication among patients with schizophrenia.
The aim of this institution based cross-sectional study was to assess attitude towards antipsychotic medications and associated factors among patients with schizophrenia who attend the outpatient clinics at Amanuel Mental Specialized Hospital, 2018.
In a cross-sectional study, 393 schizophrenic patients from Amanuel Mental Specialized Hospital were recruited by a systematic random sampling technique. Drug Attitude Inventory (DAI-10) was used to assess attitude, experience, and belief about antipsychotics. Glasgow antipsychotic side effect scale modified version, positive and negative syndrome scale, and Birch wood's insight scale for psychosis were the instruments used to assess the associated factors. Simple and multiple linear regression analysis models were fitted, and the adjusted unstandardized beta () coefficient at 95% confidence interval was used.
The mean score of attitude towards antipsychotic medications was 6.51 with standard deviation (SD) of 2.22. In multiple linear regression, positive symptoms (= -0.07, 95% CI: (-0.09, -0.05)), negative symptoms (= -0.04, 95% CI: (-0.06,-0.02)), shorter (≤5 years) duration of illness (= -0.39, 95% CI: (-0.63, -0.15)), first generation antipsychotics ( = -0.35, 95% CI: (-0.55,-0.14)), having sedation (= -0.28, 95% CI: (-0.52, -0.02)), and extra-pyramidal side effects (= -0.34, 95% CI: (-0.59,-0.09)) were factors negatively associated with attitude towards antipsychotic medication treatment. Insight to illness (= 0.24, 95% CI: (0.20, 0.27) was a factor positively associated with attitude towards antipsychotic medications.
The result suggests that the mean score of participants' attitude towards antipsychotic medications was good. Prevention of side effects particularly due to first generation antipsychotics is necessary.
对抗精神病药物的不良态度较为普遍，这是治疗依从性差的一个因素。这会增加复发风险、相关医疗资源利用及成本。本研究旨在评估精神分裂症患者对抗精神病药物的态度。
这项基于机构的横断面研究旨在评估2018年在阿马努尔精神专科医院门诊就诊的精神分裂症患者对抗精神病药物的态度及相关因素。
在一项横断面研究中，采用系统随机抽样技术从阿马努尔精神专科医院招募了393名精神分裂症患者。使用药物态度量表（DAI - 10）评估对抗精神病药物的态度、经验和信念。采用格拉斯哥抗精神病药物副作用量表修订版、阳性和阴性症状量表以及伯奇伍德精神病洞察力量表来评估相关因素。拟合简单和多元线性回归分析模型，并使用95%置信区间的调整后非标准化β系数。
对抗精神病药物态度的平均得分为6.51，标准差为2.22。在多元线性回归中，阳性症状（β = -0.07，95%置信区间：（-0.09，-0.05））、阴性症状（β = -0.04，95%置信区间：（-0.06，-0.02））、病程较短（≤5年）（β = -0.39，95%置信区间：（-0.63，-0.15））、第一代抗精神病药物（β = -0.35，95%置信区间：（-0.55，-0.14））、有镇静作用（β = -0.28，95%置信区间：（-0.52，-0.02））以及锥体外系副作用（β = -0.34，95%置信区间：（-0.59，-0.09））是与对抗精神病药物治疗态度呈负相关的因素。对疾病的洞察力（β = 0.24，95%置信区间：（0.20，0.27））是与对抗精神病药物态度呈正相关的因素。
结果表明参与者对抗精神病药物态度的平均得分良好。预防副作用尤其是第一代抗精神病药物引起的副作用是必要的。
