钆与铂协同作用：通过磁共振成像和荧光成像对药物递送进行实时多模态监测
Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging.
作者信息
Li Hongguang, Harriss Bethany I, Phinikaridou Alkystis, Lacerda Sara, Ramniceanu Gregory, Doan Bich-Thuy, Ho Ka-Lok, Chan Chi-Fai, Lo Wai-Sum, Botnar René M, Lan Rongfeng, Richard Cyrille, Law Ga-Lai, Long Nicholas J, Wong Ka-Leung
机构信息
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR.
Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
出版信息
Nanotheranostics. 2017 May 8;1(2):186-195. doi: 10.7150/ntno.18619. eCollection 2017.
A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r relaxivity of 23.4 mMs at 3T, 25 C) is a photo-activated cisplatin prodrug () which enables real-time monitoring of anti-cancer efficacy. is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control . Upon complete release of cisplatin, all is converted to enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.
本文报道了一种新型的载顺铂分子载体，它能够同时进行光学成像和磁共振成像。这种长效磁共振成像造影剂（在3T、25℃时弛豫率为23.4 mM⁻¹s⁻¹）是一种光活化顺铂前药（），可实现对抗癌疗效的实时监测。是通过磁共振成像监测药物递送和抗癌疗效的模型，在肾皮质和脾脏等多个器官中的保留时间（24小时）比钆喷酸葡胺及其基序对照长得多。顺铂完全释放后，所有转化为，从而能够在其4小时的合理清除时间内对治疗效果进行后续的磁共振成像分析。还存在响应性荧光增强，可通过光子激发进行监测。
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