Gerenutti Marli, Martinez Adriana Michel Vieira, Bergamaschi Cristiane de Cassia
Department of Pharmaceutical Sciences, Universidade de Sorocaba (UNISO), Sorocaba, Brazil.
Specialized Municipal Assistance Service (SAME) in HIV/AIDS, Sorocaba, Brazil.
Adv Pharm Bull. 2017 Sep;7(3):469-472. doi: 10.15171/apb.2017.056. Epub 2017 Sep 25.
To verify the effectiveness of a pharmaceutical care model developed by the Specialized Municipal Assistance Service in Sorocaba, Brazil, on adherence to ART among patients infected with HIV. A cohort study compared adherence to ART in two groups of patients: intervention group (patients assisted with pharmaceutical care, n=130) and non-intervention group (patients attended by the habitual dispensing process, n=229). Antiretroviral adherence was measured by the number of pharmacy refill records in a six-month period. The relationship between the use of other drugs for the treatment of opportunistic infections and the adherence rate in the intervention group and the correlation between adherence and viral load and CD4 lymphocytes were also assessed. Higher adherence rates were observed in the intervention group (p<0.05). The use of others drugs did not influence adherence to ART (p=0.30). There was a positive correlation between adherence and the percentage of patients in the intervention group with undetectable viral loads (p=0.0004) and higher levels of CD4 lymphocytes (p=0.0024). The pharmaceutical care model developed by the SAME improved patient adherence to ART as well as clinical outcomes.
为验证巴西索罗卡巴市专门市政援助服务机构开发的药学服务模式对艾滋病毒感染患者抗逆转录病毒治疗（ART）依从性的有效性。一项队列研究比较了两组患者的ART依从性：干预组（接受药学服务的患者，n = 130）和非干预组（通过常规配药流程就诊的患者，n = 229）。通过六个月内药房再填充记录的数量来衡量抗逆转录病毒治疗的依从性。还评估了用于治疗机会性感染的其他药物的使用与干预组依从率之间的关系，以及依从性与病毒载量和CD4淋巴细胞之间的相关性。干预组观察到更高的依从率（p<0.05）。使用其他药物对ART依从性没有影响（p = 0.30）。干预组中病毒载量不可检测的患者百分比与依从性之间存在正相关（p = 0.0004），CD4淋巴细胞水平较高与依从性之间也存在正相关（p = 0.0024）。SAME开发的药学服务模式提高了患者对ART的依从性以及临床结局。
