经视网膜肿瘤活检后的葡萄膜黑色素瘤细胞种植？
Uveal Melanoma Cell Seeding after Transretinal Tumor Biopsy?
作者信息
Koch Konrad R, Hishmi Ahmed M, Ortmann Monika, Heindl Ludwig M
机构信息
Department of Ophthalmology, University of Cologne, Cologne, Germany.
Department of Pathology, University of Cologne, Cologne, Germany.
出版信息
Ocul Oncol Pathol. 2017 Sep;3(3):164-167. doi: 10.1159/000453360. Epub 2017 Jan 26.
BACKGROUND/AIMS: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion.
METHODS
Interventional case report.
RESULTS
A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye. Histopathology confirmed a recurrence of uveal melanoma with intra- and extrascleral tumor portions. Serial sections revealed the posterior border of this newfound pars plana melanoma separated from the radiation scar by a viable and tumor-free choroidal area, thus failing to establish a continuity between secondary and primary tumor.
CONCLUSION
Transretinal tumor biopsy is of high diagnostic and prognostic value in the management of uveal lesions, but also bears the potential risk for tumor cell seeding.
背景/目的：报告1例疑似葡萄膜病变经视网膜肿瘤活检后发生葡萄膜黑色素瘤细胞播散的病例及其组织病理学情况。
方法
介入性病例报告。
结果
1例66岁男性，在对后极部脉络膜黑色素瘤行经视网膜活检及钌斑近距离放射治疗3.5年后，在睫状体扁平部眼内肿块上方出现色素性角膜缘巩膜表层病变。患者接受了眼球摘除术。组织病理学证实为葡萄膜黑色素瘤复发，伴有巩膜内和巩膜外肿瘤部分。连续切片显示，新发现的睫状体扁平部黑色素瘤的后缘与放射瘢痕之间被一个存活且无肿瘤的脉络膜区域隔开，因此未能在继发性和原发性肿瘤之间建立连续性。
结论
经视网膜肿瘤活检在葡萄膜病变的管理中具有很高的诊断和预后价值，但也存在肿瘤细胞播散的潜在风险。
Zotero 插件