Department of Ophthalmology, Croix-Rousse University Hospital, Lyon, France.
Acta Ophthalmol. 2013 May;91(3):279-81. doi: 10.1111/j.1755-3768.2011.02172.x. Epub 2011 May 19.
To evaluate the efficacy and the safety of uveal melanoma transretinal biopsy using 25-gauge vitrectomy system.
At the patient's request of a tissue diagnosis, nine posterior uveal melanomas treated by proton-beam therapy were biopsied during the insertion of tantalium markers.
The diagnosis was uveal melanoma, confirmed in all cases using cytological (7 of 9) and histological analysis (2 of 9). Immunocytochemistry was performed on all samples (9 of 9). In eight of nine patients, minor postoperative vitreous haemorrhages were seen, which resolved in 1 day. No other ocular complications were noticed.
Uveal melanoma biopsy using 25-gauge vitrectomy system is a valuable procedure to confirm the diagnosis, with adequate sample and low ocular morbidity.
评估使用 25 号玻璃体切割系统行视网膜巩膜透热活检治疗葡萄膜黑色素瘤的疗效和安全性。
9 例经质子束治疗的后葡萄膜黑色素瘤患者，在插入钽标记物时，出于组织诊断的要求，接受了活检。
所有病例均通过细胞学（9 例中的 7 例）和组织学分析（9 例中的 2 例）确诊为葡萄膜黑色素瘤。所有标本（9 例中的 9 例）均进行了免疫细胞化学检测。9 例中有 8 例出现轻微的术后玻璃体积血，1 天后自行消退。未发现其他眼部并发症。
使用 25 号玻璃体切割系统进行葡萄膜黑色素瘤活检是一种有价值的诊断方法，可获得足够的标本且眼部发病率低。
