泪囊慢性淋巴细胞白血病/小细胞淋巴细胞淋巴瘤：病例系列
Chronic Lymphocytic Leukaemia/ Small-Cell Lymphocytic Lymphoma of the Lacrimal Sac: A Case Series.
作者信息
Krishna Yamini, Irion Luciane D, Karim Sozan, Dharmsena Aruna, McCormick Austin, Coupland Sarah E
机构信息
Department of Cellular Pathology, Royal Liverpool and Broadgreen University Hospital Trust, Liverpool, UK.
Department of Histopathology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
出版信息
Ocul Oncol Pathol. 2017 Sep;3(3):224-228. doi: 10.1159/000455148. Epub 2017 Mar 9.
BACKGROUND
Lymphomas of the lacrimal sac are rare, accounting for less than 10% of lacrimal sac malignant tumours. They may present with symptoms typical of secondary acquired nasolacrimal duct obstruction and are thus often misdiagnosed.
METHODS
Case series and literature review.
RESULTS
Herein we describe 3 cases of chronic lymphocytic leukaemia (CLL)/small-cell lymphocytic lymphoma (SLL) of the lacrimal sac with immunohistochemical and in 1 case molecular confirmation.
CONCLUSION
Lymphomas of the lacrimal sac should be suspected in patients with known CLL presenting with epiphora and dacryocystitis. During dacryocystorhinostomy, an incisional biopsy of the lacrimal sac is essential for confirming CLL/SLL involvement and may guide treatment.
背景
泪囊淋巴瘤罕见，占泪囊恶性肿瘤的比例不到10%。它们可能表现为继发性获得性鼻泪管阻塞的典型症状，因此常被误诊。
方法
病例系列研究及文献回顾。
结果
本文描述了3例泪囊慢性淋巴细胞白血病（CLL）/小细胞淋巴细胞淋巴瘤（SLL），其中1例经免疫组化及分子检测确诊。
结论
已知患有CLL且出现溢泪和泪囊炎的患者应怀疑泪囊淋巴瘤。在进行泪囊鼻腔吻合术时，对泪囊进行切开活检对于确诊CLL/SLL累及情况至关重要，且可能指导治疗。
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