印度东部的儿童布鲁氏菌病。
Childhood Brucellosis in Eastern India.
机构信息
Brucella Research Laboratory, Peerless Hospital & B.K. Roy Research Centre, 360 Panchasayar, Kolkata, West Bengal, 700094, India.
Department of Microbiology, MGM Medical College, Kishanganj, Bihar, India.
出版信息
Indian J Pediatr. 2018 Apr;85(4):266-271. doi: 10.1007/s12098-017-2513-z. Epub 2017 Oct 26.
OBJECTIVE
To investigate the presence of childhood brucellosis presenting as PUO (pyrexia of unknown origin) cases in Eastern zone of India.
METHODS
Blood samples were collected from PUO patients aged ≤18 y. The main diagnostic tools were STAT, RBPT, ELISA- IgM, IgG and PCR. Although mainly PUO cases were selected for the study, other associated clinical manifestations were also noted.
RESULTS
The findings revealed significantly higher percentage of infection in female children (14.3%) than in male children (10.9%). The positive results by different diagnostic tools, STAT, RBPT, ELISA- IgM, ELISA-IgG and brucella genus specific PCR were 10.6%, 7.2%, 7.2%, 0.85% and 1.3% respectively. Main associated clinical symptoms were joint pain, low backache, fatigue and night sweat.
CONCLUSIONS
This hospital based study reflects a significant number of childhood brucellosis cases in Eastern zone of India, and thus emphasizes the need for further monitoring of such subjects.
目的
调查印度东部地区以不明原因发热（PUO）为表现的儿童布氏杆菌病病例的存在情况。
方法
采集≤18 岁的 PUO 患者的血样。主要的诊断工具是 STAT、RBPT、ELISA-IgM、IgG 和 PCR。尽管主要选择 PUO 病例进行研究，但也注意到了其他相关的临床表现。
结果
研究结果显示，女性儿童（14.3%）的感染率明显高于男性儿童（10.9%）。不同诊断工具的阳性结果，STAT、RBPT、ELISA-IgM、ELISA-IgG 和布鲁氏菌属特异性 PCR 分别为 10.6%、7.2%、7.2%、0.85%和 1.3%。主要的相关临床症状是关节痛、下腰痛、疲劳和夜间出汗。
结论
这项基于医院的研究反映了印度东部地区存在大量儿童布氏杆菌病病例，因此强调需要进一步监测此类人群。
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