School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
Acupunct Med. 2012 Dec;30(4):307-15. doi: 10.1136/acupmed-2011-010123. Epub 2012 Sep 15.
Objective The aim of the present work was to observe the activation/deactivation of cerebral functional regions after electroacupuncture (EA) at Yintang (EX-HN3) and GV20 by functional MRI (fMRI). Design A total of 12 healthy volunteers were stimulated by EA at Yintang and GV20 for 30 min. Resting-state fMRI scans were performed before EA, and at 5 and 15 min after needle removal. Statistical parametric mapping was used to preprocess initial data, and regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) were analysed. Results ReHo at 5 min post stimulation showed increases in the left temporal lobe and cerebellum and decreases in the left parietal lobe, occipital lobe and right precuneus. At 15 min post stimulation, ReHo showed increases in the left fusiform gyrus; lingual gyrus; middle temporal gyrus; postcentral gyrus; limbic lobe; cingulate gyrus; paracentral lobule; cerebellum, posterior lobe, declive; right cuneus and cerebellum, anterior lobe, culmen. It also showed decreases in the left frontal lobe, parietal lobe, right temporal lobe, frontal lobe, parietal lobe and right cingulate gyrus. ALFF at 5 min post stimulation showed increases in the right temporal lobe, but decreases in the right limbic lobe and posterior cingulate gyrus. At 15 min post stimulation ALFF showed increases in the left frontal lobe, parietal lobe, occipital lobe, right temporal lobe, parietal lobe, occipital lobe and cerebellum, but decreases in the left frontal lobe, anterior cingulate gyrus, right frontal lobe and posterior cingulate gyrus. Conclusions After EA stimulation at Yintang and GV20, which are associated with psychiatric disorder treatments, changes were localised in the frontal lobe, cingulate gyrus and cerebellum. Changes were higher in number and intensity at 15 min than at 5 min after needle removal, demonstrating lasting and strong after-effects of EA on cerebral functional regions.
本研究旨在通过功能磁共振成像（fMRI）观察电针（EA）刺激印堂（EX-HN3）和百会（GV20）后大脑功能区的激活/失活情况。
共 12 名健康志愿者接受 EA 刺激印堂和百会 30 分钟，在 EA 前、针拔出后 5 分钟和 15 分钟进行静息态 fMRI 扫描。使用统计参数映射预处理原始数据，并分析局部一致性（ReHo）和低频振幅（ALFF）。
刺激后 5 分钟，ReHo 显示左侧颞叶和小脑区域增加，左侧顶叶、枕叶和右侧楔前叶减少。刺激后 15 分钟，ReHo 显示左侧梭状回、舌回、颞中回、中央后回、边缘叶、扣带回、旁中央小叶、小脑后叶、蚓部、右侧楔叶和小脑前叶、山顶增加；左侧额叶、顶叶、右侧颞叶、额叶、顶叶和右侧扣带回减少。刺激后 5 分钟，ALFF 显示右侧颞叶增加，右侧边缘叶和后扣带回减少。刺激后 15 分钟，ALFF 显示左侧额叶、顶叶、枕叶、右侧颞叶、顶叶、枕叶和小脑增加，左侧额叶、前扣带回、右侧额叶和后扣带回减少。
电针刺激印堂和百会治疗精神障碍后，局部大脑功能区发生变化，在针拔出后 15 分钟比 5 分钟时变化更多、更强，表明电针对大脑功能区的持续和强烈的后效应。
