基于白藜芦醇的肉桂酸酯杂化物：合成、表征及抗炎活性

Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity.

作者信息

Ruan Ban-Feng, Ge Wei-Wei, Cheng Hui-Jie, Xu Hua-Jian, Li Qing-Shan, Liu Xin-Hua

机构信息

a School of Medical Engineering , Hefei University of Technology , Hefei , P. R. China.

b Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs , School of Pharmacy, Anhui Medical University , Hefei , P. R. China.

出版信息

J Enzyme Inhib Med Chem. 2017 Dec;32(1):1282-1290. doi: 10.1080/14756366.2017.1381090.

Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.