Braimah R O, Ndukwe K C, Owotade J F, Aregbesola S B
Department of Dental and Maxillofacial Surgery, Usmanu Danfodio University Teaching Hospital, Sokoto, Nigeria.
Department of Oral and Maxillofacial Surgery and Oral Pathology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.
Niger J Clin Pract. 2017 Sep;20(9):1189-1194. doi: 10.4103/1119-3077.183235.
To compare the impact of antibiotics on health-related quality of life (QoL) outcomes following third molar surgery.
The study population consisted of 135 subjects that required surgical extraction of mandibular third molar under local anesthesia and met the inclusion criteria. The subjects were randomized into three study groups of 45 subjects each: Group A - extended amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England), 1 gram pre-operatively and then 625 mg BD for 5 days Group B - prophylactic amoxicillin/clavulanic acid (GlaxoSmithKline Beecham England) 1 gram pre-operatively only, and Group C - prophylactic levofloxacin 1 gram pre-operatively only. Patients were assessed pre- and post-operatively on days 1, 3, 5, 7, and 14 using the United Kingdom oral health-related QoL (OHRQoL) questionnaire.
This study showed that surgical removal of impacted teeth exerted a negative influence on patient's QoL across various physical, social, and psychological aspects of life. Comparing the three groups, Group A showed a slightly better QoL score; although, there was no statistically significant difference among them. Studies have shown better clinical recovery following administration of antibiotics after third molar surgery.
There was a significant deterioration in OHRQoL in the immediate postoperative period, particularly postoperative days 1 and 3 following third molar surgery. QoL was also observed to be slightly better in Group A than Groups B and C, although this was not statistically significant.
比较抗生素对第三磨牙手术后健康相关生活质量（QoL）结果的影响。
研究人群包括135名需要在局部麻醉下手术拔除下颌第三磨牙且符合纳入标准的受试者。受试者被随机分为三个研究组，每组45名受试者：A组——术前服用1克阿莫西林/克拉维酸（英国葛兰素史克公司），然后术后5天每天两次，每次625毫克；B组——仅术前预防性服用1克阿莫西林/克拉维酸（英国葛兰素史克公司）；C组——仅术前预防性服用1克左氧氟沙星。在术后第1、3、5、7和14天，使用英国口腔健康相关生活质量（OHRQoL）问卷对患者进行术前和术后评估。
本研究表明，拔除阻生牙对患者生活的各个身体、社会和心理方面的生活质量都有负面影响。比较三组，A组的生活质量得分略高；然而，三组之间没有统计学上的显著差异。研究表明，第三磨牙手术后使用抗生素后临床恢复情况更好。
术后即刻，尤其是第三磨牙手术后的第1天和第3天，口腔健康相关生活质量显著下降。虽然A组的生活质量也略好于B组和C组，但这在统计学上并不显著。
