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通过未保护肟的卡斯塔尼奥利-库什曼反应制备的作为铁络合剂的细菌铁载体的环状异羟肟酸类似物。

Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli-Cushman Reaction of Unprotected Oximes.

作者信息

Bakulina Olga, Bannykh Anton, Dar'in Dmitry, Krasavin Mikhail

机构信息

Laboratory of Chemical Pharmacology, Saint Petersburg State University, Saint-Petersburg, 199034, Russian Federation.

出版信息

Chemistry. 2017 Dec 14;23(70):17667-17673. doi: 10.1002/chem.201704389. Epub 2017 Nov 29.

DOI:10.1002/chem.201704389
PMID:29072340
Abstract

The first application of multicomponent chemistry (the Castagnoli-Cushman reaction) toward the convenient one-step preparation of cyclic hydroxamic acids is described. Cyclic hydroxamic acids are close analogues of bacterial siderophores (iron-binding compounds) and form stable complexes with Fe ions as confirmed by spectrophotometric measurements. These compounds are potential components for the design of chelating agents for iron overload disease therapy, as well as siderophore-based carrier systems for antibiotic delivery across the bacterial cell wall.

摘要

本文描述了多组分化学（卡斯塔尼奥利-库什曼反应）首次用于便捷地一步制备环状异羟肟酸。环状异羟肟酸是细菌铁载体（铁结合化合物）的类似物，并且通过分光光度测量证实其能与铁离子形成稳定的络合物。这些化合物是用于铁过载疾病治疗的螯合剂设计的潜在成分，也是用于抗生素跨细菌细胞壁递送的基于铁载体的载体系统的潜在成分。

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