Kruakaew Sudarat, Seeka Chonticha, Lhinhatrakool Thitima, Thongnest Sanit, Yahuafai Jantana, Piyaviriyakul Suratsawadee, Siripong Pongpun, Sutthivaiyakit Somyote
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University , Hua Mark, Bangkapi, Bangkok 10240, Thailand.
College of Oriental Medicine, Rangsit University , Muang Ake, Pathumthani 12000, Thailand.
J Nat Prod. 2017 Nov 22;80(11):2987-2996. doi: 10.1021/acs.jnatprod.7b00554. Epub 2017 Oct 26.
Thirteen cardenolide glycosides (1-13) were isolated from the CHCl and MeOH extracts of Vallaris glabra leaves. The structures of the new compounds (2-13) were identified by spectroscopic methods, with the absolute configurations of the sugar moieties determined by acid hydrolysis. All compounds were evaluated for their cytotoxic activity against human cervix adenocarcinoma, lung carcinoma, and colorectal adenocarcinoma cell lines. The two most potent compounds [2'-O-acetylacoschimperoside P (1) and oleandrigenin-3-O-α-l-2'-O-acetylvallaropyranoside (2)] exhibited IC values in the range of 0.03-0.07 μM.
从毛叶娃儿藤叶的氯仿和甲醇提取物中分离得到13种强心苷糖苷（1 - 13）。通过光谱方法鉴定了新化合物（2 - 13）的结构，糖部分的绝对构型通过酸水解确定。评估了所有化合物对人宫颈腺癌、肺癌和结肠直肠腺癌细胞系的细胞毒性活性。两种活性最强的化合物[2'-O-乙酰基紫花洋地黄苷P（1）和夹竹桃苷元-3-O-α-l-2'-O-乙酰基娃儿藤吡喃糖苷（2）]的半数抑制浓度（IC）值在0.03 - 0.07μM范围内。
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