Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P. R. China.
Planta Med. 2011 Oct;77(15):1730-4. doi: 10.1055/s-0030-1271045. Epub 2011 Apr 20.
Bioassay-guided fractionation of the ethanolic extract from the seeds of Antiaris toxicaria led to the isolation of three new cardiac glycosides named toxicarioside J, toxicarioside K, and toxicarioside L, together with a known glucostrophalloside. The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and 1D, 2D NMR techniques. The cytotoxic activities of these cardiac glycosides against human gastric (SGC-7901) and human hepatoma (SMMC-7721) cell lines were evaluated, and all of them exhibited significant cytotoxicity.
生物测定指导下，从 Antiaris toxicaria 种子的乙醇提取物中进行分段分离，得到了三种新的强心苷，分别命名为 toxicarioside J、toxicarioside K 和 toxicarioside L，以及一种已知的 glucostrophalloside。通过包括高分辨质谱、紫外、红外和 1D、2D NMR 技术在内的光谱方法阐明了这些新化合物的结构。评估了这些强心苷对人胃癌（SGC-7901）和人肝癌（SMMC-7721）细胞系的细胞毒性活性，它们都表现出显著的细胞毒性。
