Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
J Nat Med. 2011 Jul;65(3-4):629-32. doi: 10.1007/s11418-011-0530-1. Epub 2011 Apr 6.
Complete (1)H and (13)C NMR assignments of acoschimperoside P, 2'-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.
描述了从山黧豆属植物的叶子中分离得到的 acoschimperoside P 的（1）H 和（13）C NMR 全归属和 2'- 乙酸酯（1）和一种新的强心苷（2）。化合物 1 在 Hedgehog 信号抑制测定中具有活性。在进一步的实验中，该化合物对人胰腺（PANC1）和人前列腺（DU145）癌细胞表现出强烈的细胞毒性。1 还以剂量依赖的方式抑制 GLI 相关蛋白（PTCH 和 BCL-2）的表达。
