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Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase.
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Targeting the Water Network in Cyclin G-Associated Kinase (GAK) with 4-Anilino-quin(az)oline Inhibitors.
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4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2).
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Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.
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Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.
J Med Chem. 2015 Apr 23;58(8):3393-410. doi: 10.1021/jm501759m. Epub 2015 Apr 9.
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Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors.
Bioorg Med Chem. 2014 Mar 15;22(6):1909-15. doi: 10.1016/j.bmc.2014.01.044. Epub 2014 Jan 31.
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Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.
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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Nat Commun. 2025 Jul 10;16(1):6397. doi: 10.1038/s41467-025-61759-1.
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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
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Utilization of Supervised Machine Learning to Understand Kinase Inhibitor Toxophore Profiles.
Int J Mol Sci. 2023 Mar 7;24(6):5088. doi: 10.3390/ijms24065088.
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Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies.
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Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype.
ChemMedChem. 2022 Jun 20;17(12):e202200161. doi: 10.1002/cmdc.202200161. Epub 2022 May 9.
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Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors.
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Progress towards a public chemogenomic set for protein kinases and a call for contributions.
PLoS One. 2017 Aug 2;12(8):e0181585. doi: 10.1371/journal.pone.0181585. eCollection 2017.
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Endocytic control of signaling at the plasma membrane.
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Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
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Target engagement and drug residence time can be observed in living cells with BRET.
Nat Commun. 2015 Dec 3;6:10091. doi: 10.1038/ncomms10091.
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KLIFS: a structural kinase-ligand interaction database.
Nucleic Acids Res. 2016 Jan 4;44(D1):D365-71. doi: 10.1093/nar/gkv1082. Epub 2015 Oct 22.
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Application of BRET to monitor ligand binding to GPCRs.
Nat Methods. 2015 Jul;12(7):661-663. doi: 10.1038/nmeth.3398. Epub 2015 Jun 1.
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NanoBRET--A Novel BRET Platform for the Analysis of Protein-Protein Interactions.
ACS Chem Biol. 2015 Aug 21;10(8):1797-804. doi: 10.1021/acschembio.5b00143. Epub 2015 Jun 9.
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FDA-approved small-molecule kinase inhibitors.
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