Koc Guray, Gokcil Zeki, Bek Semai, Kasikci Tayfun, Eroglu Erdal, Odabasi Zeki
Department Of Neurology, Gulhane Training and Research Hospital, Ankara, Turkey.
Department Of Neurology, Gulhane Training and Research Hospital, Ankara, Turkey.
Epilepsy Behav. 2017 Dec;77:26-29. doi: 10.1016/j.yebeh.2017.09.011. Epub 2017 Oct 23.
Transcranial magnetic stimulation (TMS) is a noninvasive technique for investigating cortical physiologic functions in the brain. In this study, the effects of continuous theta burst stimulation (cTBS) on motor evoked potential (MEP) parameters in patients with idiopathic generalized epilepsy (IGE) were investigated.
Fifteen patients with IGE were included. Motor threshold (MT) and cortical silent period (CSP) were determined before cTBS application. Next, cTBS was applied to the dominant (left) hemisphere M1 hand area as the first application. After 1 day, cTBS was applied first to the left M1 hand area and then to the right lateral cerebellar area as the second application. Parameters were again determined after the applications.
There was no difference in resting MT values before and after cTBS application (p>0.05). Although CSP increased after stimulation (p<0.05), it was not significantly different between applications (p>0.05).
For patients with epilepsy, cTBS is a safe technique when applied at a low intensity. The inhibitory effect of cTBS, a noninvasive technique, on cortical excitability in patients with IGE was determined using MEP parameters. The effect lasted at least 1 h. To our knowledge, this is the first study to assess the effect of cTBS on cortical excitability in patients with IGE. Our findings indicate that cTBS decreases cortical excitability in patients with IGE.
经颅磁刺激（TMS）是一种用于研究大脑皮质生理功能的非侵入性技术。在本研究中，我们调查了连续θ波爆发刺激（cTBS）对特发性全身性癫痫（IGE）患者运动诱发电位（MEP）参数的影响。
纳入15例IGE患者。在应用cTBS之前测定运动阈值（MT）和皮质静息期（CSP）。接下来，将cTBS作为首次应用施加于优势（左侧）半球M1手部区域。1天后，将cTBS作为第二次应用先施加于左侧M1手部区域，然后施加于右侧小脑外侧区域。应用后再次测定参数。
应用cTBS前后静息MT值无差异（p>0.05）。虽然刺激后CSP增加（p<0.05），但两次应用之间无显著差异（p>0.05）。
对于癫痫患者，低强度应用cTBS是一种安全的技术。使用MEP参数确定了cTBS这种非侵入性技术对IGE患者皮质兴奋性的抑制作用。该作用至少持续1小时。据我们所知，这是第一项评估cTBS对IGE患者皮质兴奋性影响的研究。我们的研究结果表明，cTBS可降低IGE患者的皮质兴奋性。
