Yanagisawa A, Lefer A M
Second Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Jpn Circ J. 1988 Dec;52(12):1436-40. doi: 10.1253/jcj.52.1436.
The pharmacological activities of synthetic atrial natriuretic factor (ANF) on cat coronary artery were studied in vitro. In the preparation of isolated cat coronary artery perfused at a constant flow, ANF (3-300 nM) decreased perfusion pressure in a concentration dependent manner, indicating coronary vasodilating activity. ANF also relaxed feline coronary strips when contracted by U-46,619, CTA2, angiotensin II, serotonin, leukotriene C4 and D4. This relaxant effect was independent in the presence of endothelial cells and occurred in the presence of guanylate cyclase inhibitor, methylene blue. ANF had no direct effect on electrically driven isolated cat papillary muscles signifying a lack of direct inotropic activity. It can be concluded that ANF may potentiate coronary vasodilation and therefore contribute to coronary regulation, without directly altering myocardial performance.
在体外研究了合成心房利钠因子（ANF）对猫冠状动脉的药理活性。在制备以恒定流量灌注的离体猫冠状动脉时，ANF（3 - 300 nM）以浓度依赖性方式降低灌注压力，表明具有冠状动脉舒张活性。当U - 46,619、CTA2、血管紧张素II、5 - 羟色胺、白三烯C4和D4使猫冠状动脉条收缩时，ANF也能使其舒张。这种舒张作用在内皮细胞存在时不受影响，且在鸟苷酸环化酶抑制剂亚甲蓝存在时也会出现。ANF对电驱动的离体猫乳头肌没有直接作用，这表明缺乏直接的变力活性。可以得出结论，ANF可能增强冠状动脉舒张，从而有助于冠状动脉调节，而不会直接改变心肌功能。
