Ertl G, Bauer B, Gaudron P, Kolb M, Kochsiek K
Medizinische Klinik, Universität Würzburg, Germany.
Eur J Clin Invest. 1992 Aug;22(8):516-22. doi: 10.1111/j.1365-2362.1992.tb01499.x.
The direct vascular action of atrial natriuretic factor (ANF) is unclear. In coronary vasculature, vasodilation has been reported as well as vasoconstriction. Doses of ANF, baseline plasma ANF levels and interference with the renin-angiotensin system might account for the controversy. We tried to further analyse determinants of the effect of ANF on coronary blood flow in anaesthetized dogs. The chest was opened and the left anterior descending coronary artery cannulated and perfused at constant normal (= 76 +/- 5 mmHg, n = 10) or reduced (= 37 +/- 3 mmHg, n = 10) pressure from the femoral arteries. At normal coronary perfusion pressure, ANF (1 ng kg-1 i.c.) reduced coronary flow from 30.7 +/- 4.2 to 26.9 +/- 4.0 ml min-1 (P less than 0.05). This effect was no longer significant at reduced coronary perfusion pressure (4.9 +/- 0.8 vs. 4.6 +/- 0.7 ml min-1). ANF (1 ng kg-1 i.c.) reduced coronary blood flow in correlation with baseline plasma ANF levels (r = 0.77, P less than 0.001). However the large variability of the constrictor effect of ANF in the rather small range of baseline plasma ANF, weakens the importance of this result and suggests other additional determinants. ANF (100 ng kg-1 i.c.) significantly increased coronary blood flow by 16-23% (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
心房利钠因子（ANF）的直接血管作用尚不清楚。在冠状动脉系统中，既有血管舒张的报道，也有血管收缩的报道。ANF的剂量、血浆ANF基线水平以及对肾素-血管紧张素系统的干扰可能是造成这种争议的原因。我们试图进一步分析ANF对麻醉犬冠状动脉血流影响的决定因素。打开胸腔，将左冠状动脉前降支插管，并通过股动脉以正常恒定（=76±5mmHg，n = 10）或降低（=37±3mmHg，n = 10）的压力进行灌注。在正常冠状动脉灌注压力下，ANF（1 ng·kg-1静脉注射）使冠状动脉血流从30.7±4.2降至26.9±4.0 ml·min-1（P<0.05）。在降低的冠状动脉灌注压力下，这种作用不再显著（4.9±0.8 vs. 4.6±0.7 ml·min-1）。ANF（1 ng·kg-1静脉注射）降低冠状动脉血流与血浆ANF基线水平相关（r = 0.77，P<0.001）。然而，在相当小的血浆ANF基线范围内，ANF的收缩作用存在很大变异性，削弱了这一结果的重要性，并提示存在其他额外的决定因素。ANF（100 ng·kg-1静脉注射）使冠状动脉血流显著增加16 - 23%（P<0.05）。（摘要截短于250字）
