脑内神经胶质细胞在脑可塑性、内稳态和精神疾病中的作用。
Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders.
机构信息
Stanford University, Department of Psychiatry and Behavioral Sciences, United States.
SUNY, Stony Brook, Department of Pharmacological Sciences, United States.
出版信息
Curr Opin Neurobiol. 2017 Dec;47:93-103. doi: 10.1016/j.conb.2017.09.016. Epub 2017 Oct 23.
Abstract
Adult oligodendrocyte progenitor cells are uniformly distributed in both gray and white matter, displaying robust proliferative and migratory potential during health and disease. Recently, developments in new experimental approaches have brought about several novel insights about NG2-glia and myelinating oligodendrocytes, indicating a diverse toolkit of functions in experience-dependent myelination and homeostasis in the adult CNS. In this review, we summarize some of the topical studies that highlight newly emerging findings implicating oligodendroglia-lineage cells in brain plasticity, homeostasis and pathophysiology of neuropsychiatric disorders.
摘要
成体少突胶质前体细胞均匀分布于灰质和白质中，在健康和疾病状态下具有强大的增殖和迁移潜能。最近，新的实验方法的发展带来了关于 NG2 胶质细胞和髓鞘形成少突胶质细胞的一些新见解，表明在成年中枢神经系统中，经验依赖性髓鞘形成和稳态存在多样化的功能工具包。在这篇综述中，我们总结了一些热门研究，这些研究强调了少突胶质细胞谱系细胞在大脑可塑性、稳态和神经精神疾病病理生理学中的新发现。
相似文献
1
Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders.脑内神经胶质细胞在脑可塑性、内稳态和精神疾病中的作用。
Curr Opin Neurobiol. 2017 Dec;47:93-103. doi: 10.1016/j.conb.2017.09.016. Epub 2017 Oct 23.
2
From precursors to myelinating oligodendrocytes: contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain.从少突胶质前体细胞到髓鞘形成少突胶质细胞：内在和外在因素对成人大脑白质可塑性的作用
Neuroscience. 2014 Jun 6;269:343-66. doi: 10.1016/j.neuroscience.2014.03.063. Epub 2014 Apr 8.
3
NG2-glia, More Than Progenitor Cells.NG2胶质细胞，不止是祖细胞。
Adv Exp Med Biol. 2016;949:27-45. doi: 10.1007/978-3-319-40764-7_2.
4
Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain.雷帕霉素靶蛋白复合物 1（mTORC1）依赖性髓鞘形成中 RHEB1 对少突胶质前体细胞内在作用的调控
J Neurosci. 2014 Nov 19;34(47):15764-78. doi: 10.1523/JNEUROSCI.2267-14.2014.
5
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.NG2 胶质细胞调节神经免疫反应，以维持神经元的功能和存活。
Sci Rep. 2017 Feb 14;7:42041. doi: 10.1038/srep42041.
6
Myelin plasticity in adulthood and aging.成年期和衰老过程中的髓鞘可塑性。
Neurosci Lett. 2020 Jan 10;715:134645. doi: 10.1016/j.neulet.2019.134645. Epub 2019 Nov 22.
7
GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury.表达GPR17的NG2神经胶质细胞：损伤后作为储备池的少突胶质前体细胞。
Glia. 2016 Feb;64(2):287-99. doi: 10.1002/glia.22929. Epub 2015 Oct 14.
8
Diversity of oligodendrocytes and their progenitors.少突胶质细胞及其前体细胞的多样性。
Curr Opin Neurobiol. 2017 Dec;47:73-79. doi: 10.1016/j.conb.2017.09.015. Epub 2017 Oct 24.
9
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity.多突胶质细胞（NG2细胞）：具有谱系可塑性的多功能细胞。
Nat Rev Neurosci. 2009 Jan;10(1):9-22. doi: 10.1038/nrn2495.
10
Unbiased stereological analysis of the fate of oligodendrocyte progenitor cells in the adult mouse brain and effect of reference memory training.成年小鼠大脑中少突胶质细胞祖细胞命运的无偏立体学分析及参考记忆训练的影响。
Behav Brain Res. 2017 Jun 30;329:127-139. doi: 10.1016/j.bbr.2017.04.027. Epub 2017 Apr 23.
引用本文的文献
1
Multiomic single-cell profiling identifies critical regulators of postnatal brain.多组学单细胞分析确定了出生后脑的关键调节因子。
Nat Genet. 2025 Mar;57(3):591-603. doi: 10.1038/s41588-025-02083-8. Epub 2025 Feb 17.
2
Oligodendroglia Are Primed for Antigen Presentation in Response to Chronic Stress-Induced Microglial-Derived Inflammation.少突胶质细胞在慢性应激诱导的小胶质细胞源性炎症反应中被激活以进行抗原呈递。
Glia. 2025 Jun;73(6):1130-1147. doi: 10.1002/glia.24661. Epub 2024 Dec 24.
3
Stress-induced c-fos expression in the medial prefrontal cortex differentially affects the main residing cell phenotypes.应激诱导的内侧前额叶皮质中c-fos表达对主要驻留细胞表型有不同影响。
Heliyon. 2024 Oct 12;10(20):e39325. doi: 10.1016/j.heliyon.2024.e39325. eCollection 2024 Oct 30.
4
Utilizing hiPSC-derived oligodendrocytes to study myelin pathophysiology in neuropsychiatric and neurodegenerative disorders.利用人诱导多能干细胞衍生的少突胶质细胞研究神经精神疾病和神经退行性疾病中的髓鞘病理生理学。
Front Cell Neurosci. 2024 Jan 11;17:1322813. doi: 10.3389/fncel.2023.1322813. eCollection 2023.
5
What Are the Roles of Oligodendrocyte Precursor Cells in Normal and Pathologic Conditions?少突胶质前体细胞在正常和病理条件下的作用是什么？
Neurology. 2023 Nov 21;101(21):958-965. doi: 10.1212/WNL.0000000000208000.
6
Integrative Analyses of scRNA-seq, Bulk mRNA-seq, and DNA Methylation Profiling in Depressed Suicide Brain Tissues.抑郁自杀脑组织中单细胞 RNA-seq、 bulk mRNA-seq 和 DNA 甲基化谱的综合分析。
Int J Neuropsychopharmacol. 2023 Dec 18;26(12):840-855. doi: 10.1093/ijnp/pyad057.
7
The role and potential therapeutic targets of astrocytes in central nervous system demyelinating diseases.星形胶质细胞在中枢神经系统脱髓鞘疾病中的作用及潜在治疗靶点
Front Cell Neurosci. 2023 Sep 1;17:1233762. doi: 10.3389/fncel.2023.1233762. eCollection 2023.
8
Single-Cell RNA Sequencing and Its Applications in the Study of Psychiatric Disorders.单细胞RNA测序及其在精神疾病研究中的应用。
Biol Psychiatry Glob Open Sci. 2022 Apr 6;3(3):329-339. doi: 10.1016/j.bpsgos.2022.03.013. eCollection 2023 Jul.
9
Heterogeneity and regulation of oligodendrocyte morphology.少突胶质细胞形态的异质性与调控
Front Cell Dev Biol. 2022 Oct 24;10:1030486. doi: 10.3389/fcell.2022.1030486. eCollection 2022.
10
Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia.组蛋白乙酰化和甲基化是精神分裂症中少突胶质细胞和髓鞘易感性的基础。
Front Cell Neurosci. 2022 Mar 10;16:823708. doi: 10.3389/fncel.2022.823708. eCollection 2022.
本文引用的文献
1
A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis.特定的 GABA 能突触到少突胶质前体细胞上不会调节皮质少突胶质发生。
Glia. 2017 Nov;65(11):1821-1832. doi: 10.1002/glia.23197. Epub 2017 Aug 10.
2
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.神经回路特异性星形胶质细胞：转录组学、蛋白质组学、形态学及功能证据
Neuron. 2017 Aug 2;95(3):531-549.e9. doi: 10.1016/j.neuron.2017.06.029. Epub 2017 Jul 14.
3
Chronic social defeat reduces myelination in the mouse medial prefrontal cortex.慢性社会挫败可减少小鼠内侧前额叶皮质的髓鞘形成。
Sci Rep. 2017 Apr 18;7:46548. doi: 10.1038/srep46548.
4
Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation.胶质细胞及其在成人大脑中的功能：对其消融历史的探索。
Front Cell Neurosci. 2017 Feb 13;11:24. doi: 10.3389/fncel.2017.00024. eCollection 2017.
5
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival.NG2 胶质细胞调节神经免疫反应，以维持神经元的功能和存活。
Sci Rep. 2017 Feb 14;7:42041. doi: 10.1038/srep42041.
6
Functional diversity of astrocytes in neural circuit regulation.星形胶质细胞在神经回路调节中的功能多样性。
Nat Rev Neurosci. 2017 Jan;18(1):31-41. doi: 10.1038/nrn.2016.159. Epub 2016 Dec 1.
7
Understanding the NG2 Glial Scar after Spinal Cord Injury.了解脊髓损伤后的NG2胶质瘢痕。
Front Neurol. 2016 Nov 15;7:199. doi: 10.3389/fneur.2016.00199. eCollection 2016.
8
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.对19个脑区的综合网络分析确定了阿尔茨海默病选择性区域易损性背后的分子特征和网络。
Genome Med. 2016 Nov 1;8(1):104. doi: 10.1186/s13073-016-0355-3.
9
NG2 glial cells integrate synaptic input in global and dendritic calcium signals.NG2神经胶质细胞在整体和树突状钙信号中整合突触输入。
Elife. 2016 Sep 19;5:e16262. doi: 10.7554/eLife.16262.
10
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning.在运动技能学习的最初阶段，需要快速产生新的少突胶质细胞。
Nat Neurosci. 2016 Sep;19(9):1210-1217. doi: 10.1038/nn.4351. Epub 2016 Jul 25.
Zotero 插件