Stanford University, Department of Psychiatry and Behavioral Sciences, United States.
SUNY, Stony Brook, Department of Pharmacological Sciences, United States.
Curr Opin Neurobiol. 2017 Dec;47:93-103. doi: 10.1016/j.conb.2017.09.016. Epub 2017 Oct 23.
Adult oligodendrocyte progenitor cells are uniformly distributed in both gray and white matter, displaying robust proliferative and migratory potential during health and disease. Recently, developments in new experimental approaches have brought about several novel insights about NG2-glia and myelinating oligodendrocytes, indicating a diverse toolkit of functions in experience-dependent myelination and homeostasis in the adult CNS. In this review, we summarize some of the topical studies that highlight newly emerging findings implicating oligodendroglia-lineage cells in brain plasticity, homeostasis and pathophysiology of neuropsychiatric disorders.
成体少突胶质前体细胞均匀分布于灰质和白质中，在健康和疾病状态下具有强大的增殖和迁移潜能。最近，新的实验方法的发展带来了关于 NG2 胶质细胞和髓鞘形成少突胶质细胞的一些新见解，表明在成年中枢神经系统中，经验依赖性髓鞘形成和稳态存在多样化的功能工具包。在这篇综述中，我们总结了一些热门研究，这些研究强调了少突胶质细胞谱系细胞在大脑可塑性、稳态和神经精神疾病病理生理学中的新发现。
