Riedler J
Kinderspital Salzburg.
Padiatr Padol. 1988;23(4):343-8.
A toxicological investigation of urine could finally explain abnormal neurological symptoms with apnea. 2 Cibalen-suppositories for children were given to an 7 week old infant as treatment of an upper respiratory infect. 12 hours were between the application of the 2 suppositories. 2 hours after the second application coma, hypertonus, opisthotonus, miosis and depression of ventilation were found. 10 hours later an apnea occurred. These symptoms were due to the synergistic effect of Phenobarbital, Aminophenazon and Codeinphosphat in an overhigh dose.
对尿液进行毒理学调查最终可能解释伴有呼吸暂停的异常神经症状。一名7周大的婴儿因上呼吸道感染接受了2枚儿童用西巴伦栓剂治疗。两次用药间隔12小时。第二次用药后2小时,发现婴儿出现昏迷、肌张力亢进、角弓反张、瞳孔缩小和通气抑制。10小时后出现呼吸暂停。这些症状是由于苯巴比妥、氨基非那宗和磷酸可待因剂量过高产生的协同作用所致。