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血管内主动脉瘤修复术后入住重症监护病房主要取决于医院因素,会增加显著的成本,而且往往是不必要的。

Intensive care unit admission after endovascular aortic aneurysm repair is primarily determined by hospital factors, adds significant cost, and is often unnecessary.

机构信息

Division of Vascular Surgery and Endovascular Therapy, Johns Hopkins Medical Institutes, Baltimore, Md.

The Johns Hopkins Surgery Center for Outcomes Research, Johns Hopkins School of Medicine, Baltimore, Md.

出版信息

J Vasc Surg. 2018 Apr;67(4):1091-1101.e4. doi: 10.1016/j.jvs.2017.07.139. Epub 2017 Oct 23.

Abstract

BACKGROUND

A large proportion of endovascular aortic aneurysm repair (EVAR) patients are routinely admitted to the intensive care unit (ICU) for postoperative observation. In this study, we aimed to describe the factors associated with ICU admission after EVAR and to compare the outcomes and costs associated with ICU vs non-ICU observation.

METHODS

All patients undergoing elective infrarenal EVAR in the Premier database (2009-2015) were included. Patients were stratified as ICU vs non-ICU admission according to location on postoperative day 0. Both patient-level (sociodemographics, comorbidities) and hospital-level (teaching status, hospital size, geographic location) factors were analyzed using univariate and multivariable logistic regression to determine factors associated with ICU vs non-ICU admission. Overall outcomes and hospital costs were compared between groups.

RESULTS

Overall, 8359 patients underwent elective EVAR during the study period, including 4791 (57.3%) ICU and 3568 (42.7%) non-ICU admissions. Patients admitted to ICU were more frequently nonwhite and had more comorbidities, including congestive heart failure, coronary artery disease, chronic kidney disease, chronic obstructive pulmonary disease, diabetes, and hypertension, than non-ICU patients (all, P < .03). ICU admissions were more common in small (<300 beds), urban, and nonteaching hospitals and varied greatly depending on surgeon specialty and geographic region (P < .001). A pattern emerged when admission location was clustered by hospital; ICU patients were treated at hospitals where 96.7% (interquartile range, 84.5%-98.9%) of patients were admitted to ICU after EVAR, whereas non-ICU patients were treated at hospitals where only 7.5% (interquartile range, 4.9%-25.8%) were admitted to ICU after EVAR. A multivariable logistic regression model accounting for patient-, operative-, and hospital-level differences had a significantly lower area under the curve for predicting ICU admission after EVAR than a model accounting only for hospital factors (area under the curve, 0.76 vs 0.95; P < .001). The overall rate of adverse events was higher for ICU vs non-ICU patients (16.3% vs 13.7%; P < .001). Failure to rescue (2.9% vs 3.9%; P = .42) and in-hospital mortality (0.4% vs 0.4%; P = .81) were similar between groups. After adjusting for patient and hospital factors as well as for postoperative adverse events, ICU admission after EVAR cost $1475 (95% confidence interval, $768-2183) more than non-ICU admission (P < .001).

CONCLUSIONS

Among patients undergoing elective EVAR, postoperative ICU admission is more closely associated with hospital practice patterns than with individual patient risk. Routine ICU admission after EVAR adds significant cost without reducing failure to rescue or in-hospital mortality.

摘要

背景

很大一部分血管内主动脉瘤修复(EVAR)患者通常在重症监护病房(ICU)接受术后观察。在这项研究中,我们旨在描述 EVAR 术后入住 ICU 的相关因素,并比较 ICU 与非 ICU 观察的结果和成本。

方法

纳入 Premier 数据库(2009-2015 年)中所有接受择期腹主动脉下段 EVAR 的患者。根据术后第 0 天的位置,将患者分为 ICU 与非 ICU 入院。使用单变量和多变量逻辑回归分析患者水平(社会人口统计学、合并症)和医院水平(教学状态、医院规模、地理位置)因素,以确定与 ICU 与非 ICU 入院相关的因素。比较两组的总体结局和医院费用。

结果

在研究期间,共有 8359 例患者接受了择期 EVAR,其中 4791 例(57.3%)入住 ICU,3568 例(42.7%)入住非 ICU。与非 ICU 患者相比,入住 ICU 的患者更常见为非白人,且合并症更多,包括充血性心力衰竭、冠心病、慢性肾脏病、慢性阻塞性肺疾病、糖尿病和高血压(均 P<.03)。小(<300 床)、城市和非教学医院的 ICU 入院更为常见,且根据外科医生专业和地理位置的不同而差异很大(P<.001)。当根据医院对入院位置进行聚类时,出现了一种模式;96.7%(四分位距,84.5%-98.9%)的患者在 EVAR 后入住 ICU 的医院,将 ICU 患者收治在 ICU,而仅 7.5%(四分位距,4.9%-25.8%)的患者在 EVAR 后入住 ICU 的医院将非 ICU 患者收治在非 ICU。一个考虑了患者、手术和医院水平差异的多变量逻辑回归模型预测 EVAR 后 ICU 入院的曲线下面积明显低于仅考虑医院因素的模型(曲线下面积,0.76 比 0.95;P<.001)。与非 ICU 患者相比,ICU 患者的总体不良事件发生率更高(16.3%比 13.7%;P<.001)。未抢救(2.9%比 3.9%;P=.42)和院内死亡率(0.4%比 0.4%;P=.81)在两组之间相似。在调整了患者和医院因素以及术后不良事件后,EVAR 后 ICU 入院的费用比非 ICU 入院多 1475 美元(95%置信区间,768-2183 美元)(P<.001)。

结论

在接受择期 EVAR 的患者中,术后 ICU 入院与医院的治疗模式更为密切相关,而与患者个体风险关系不大。EVAR 后常规 ICU 入院增加了显著的成本,而没有降低未抢救或院内死亡率。

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