Department of Psychology, University of Otago, New Zealand, PO Box 56, Dunedin 9054, New Zealand.
Department of Psychology, University of Otago, New Zealand, PO Box 56, Dunedin 9054, New Zealand.
Schizophr Res. 2018 May;195:154-159. doi: 10.1016/j.schres.2017.10.028. Epub 2017 Nov 1.
Clinical and epidemiological studies have demonstrated associations between elevated intra-individual variability (IIV) of reaction time and psychotic disorders. However, little attention has been paid to the relationship between performance stability and psychotic-like experiences (PLE) in adolescence, before psychotic disorder onset. Data from 6702 children from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to address this issue. Children took part in a semi-structured clinical interview regarding psychotic symptoms at age 12 and 18, and reaction time variability was assessed at age 13 and 15. Children who had elevated IIV at age 15 were more likely to report suspected or definite PLE at age 18, with larger associations being found for more frequent or bizarre symptoms. Elevated IIV at age 15 was also associated with persistent PLE between age 12 and 18. These findings tentatively suggest that elevated IIV in early adolescence may be predictive of later PLE, and offer some support for the notion of a psychosis continuum.
临床和流行病学研究表明，个体内反应时变异（IIV）升高与精神障碍之间存在关联。然而，在精神障碍发病前的青少年时期，人们对与类精神病体验（PLE）相关的表现稳定性关注甚少。本研究使用来自阿冯纵向研究父母和儿童（ALSPAC）的 6702 名儿童的数据来解决这个问题。在 12 岁和 18 岁时，儿童接受了关于精神病症状的半结构化临床访谈，在 13 岁和 15 岁时评估了反应时变异性。在 15 岁时 IIV 升高的儿童更有可能在 18 岁时报告疑似或明确的 PLE，更频繁或更离奇的症状与更大的关联有关。在 15 岁时 IIV 升高也与 12 岁至 18 岁之间持续的 PLE 相关。这些发现初步表明，青少年早期 IIV 升高可能预示着以后的 PLE，为精神病连续性的概念提供了一些支持。
