Sawatsubashi Shun
Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Japan.
Clin Calcium. 2017;27(11):1629-1635.
Active vitamin D and analogs exert immunomodulatory effects and potent effects on cellular differentiation and proliferation in the skin. In the last few decades, it has convincingly been shown that these analogs are effective and safe in the topical treatment of psoriasis, where they nowadays represent a standard therapy. However, the mechanism of vitamin D action in the treatment of psoriasis remains largely unknown. Here, we reviewed and discussed the recent findings of molecular action of vitamin D in psoriasis.
活性维生素D及其类似物具有免疫调节作用，并对皮肤细胞的分化和增殖有显著影响。在过去几十年中，已有确凿证据表明，这些类似物在银屑病的局部治疗中有效且安全，如今已成为标准疗法。然而，维生素D治疗银屑病的作用机制仍 largely未知。在此，我们回顾并讨论了维生素D在银屑病中分子作用的最新研究结果。
