Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy -
Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Minerva Endocrinol. 2020 Jun;45(2):138-147. doi: 10.23736/S0391-1977.20.03190-9. Epub 2020 Apr 27.
Psoriasis is a common chronic immune-mediated inflammatory skin disease, now considered a systemic inflammatory process with several comorbidities. The skin produces vitamin D by the action of ultraviolet light. Vitamin D performs various immunomodulatory, anti-inflammatory, antioxidant and antifibrotic actions. The immunomodulatory effects of vitamin D offer opportunities to improve the treatment of several autoimmune diseases, such as psoriasis. In the literature, several significant associations are reported between low levels of vitamin D and psoriasis. Today, topical vitamin D represents an important therapeutic option due to its action on the proliferation and maturation of keratinocytes. The situation is different regarding the oral intake and integration of vitamin D in psoriasis patients. The use of vitamin D supplementation as an adjunctive treatment option in these patients is still discussed. This work aims to analyze the association between psoriasis and vitamin D levels according to dermatologists and nutritionists.
银屑病是一种常见的慢性免疫介导的炎症性皮肤病，现在被认为是一种全身性炎症过程，伴有多种合并症。皮肤通过紫外线的作用产生维生素 D。维生素 D 具有多种免疫调节、抗炎、抗氧化和抗纤维化作用。维生素 D 的免疫调节作用为改善几种自身免疫性疾病（如银屑病）的治疗提供了机会。在文献中，报道了维生素 D 水平低与银屑病之间存在多种显著关联。如今，由于维生素 D 对角质形成细胞的增殖和成熟有作用，局部用维生素 D 成为一种重要的治疗选择。但在银屑病患者中口服摄入和整合维生素 D 的情况则不同。关于在这些患者中使用维生素 D 补充剂作为辅助治疗选择的问题仍在讨论中。本工作旨在根据皮肤科医生和营养师的观点来分析银屑病与维生素 D 水平之间的关联。
