Prakash Gaurav, Yanamandra Uday, Khadwal Alka, Varma Neelam, Varma Subhash, Malhotra Pankaj
Clinical Hematology Division, Department of Internal Medicine, PGIMER, Chandigarh, 160012 India.
Department of Hematology, PGIMER, Chandigarh, 160012 India.
Indian J Hematol Blood Transfus. 2017 Dec;33(4):534-536. doi: 10.1007/s12288-017-0795-y. Epub 2017 Feb 23.
Aplastic anemia is a common problem in the developing world with therapeutic challenges as most of the patients are non-affording to standard care owing to resource constraints. We present the results of an open label single arm, non-randomized, single center, prospective phase II trial of the compassionate use of arsenic trioxide in patients refractory to ATG or unable to afford the standard of care therapy. The study was prematurely terminated at eighth week due to non-response in 100% of patients and death in two patients. The results are contradictory to what is already published and needs validation in a multicentric setting.
再生障碍性贫血在发展中世界是一个常见问题，存在治疗挑战，因为由于资源限制，大多数患者无法负担标准治疗。我们展示了一项开放标签单臂、非随机、单中心、前瞻性II期试验的结果，该试验是关于对抗胸腺细胞球蛋白（ATG）难治或无法负担标准治疗的患者同情使用三氧化二砷。由于100%的患者无反应以及两名患者死亡，该研究在第八周提前终止。结果与已发表的内容相矛盾，需要在多中心环境中进行验证。
