Ahamed M, Anand M, Kumar A, Siddiqui M K J
Analytical Toxicology, Industrial Toxicology Research Centre, P.O. Box-80, M.G. Marg, Lucknow-226 001, India.
Clin Biochem. 2006 Jul;39(7):762-6. doi: 10.1016/j.clinbiochem.2006.03.021. Epub 2006 Apr 21.
A hospital-based case-control study, the first in India, was conducted to determine the incidence of childhood aplastic anaemia in and around Lucknow in the backdrop of organochlorine levels in the blood and review the database for any association between the disease and exposure to pesticides.
A total of 25 cases of childhood aplastic anaemia were identified as per established criteria and enrolled over the study period of 1 year. Their blood organochlorine levels were determined using a gas-liquid chromatograph equipped with an electron capture detector.
The annual incidence of childhood aplastic anaemia in and around Lucknow was found to be 6.8 cases per million which is higher than many countries (e.g., France, Brazil, UK, and United States) but lower than those reported in Sweden, China and an European-Israeli collaborative study. Blood levels of alpha-HCH, gamma-HCH, delta-HCH, total-HCH, and p, p'-DDE were higher in children with aplastic anaemia than in those of controls; only alpha-HCH differed significantly (P < 0.05).
Although this pilot study, with limited statistical power, did not support any association between exposure to organochlorines and risk of childhood aplastic anaemia, a possible association between the two could not be ruled out in view of several cases identified following exposure to pesticides.
在印度开展了一项基于医院的病例对照研究，这是该国首例此类研究，旨在确定勒克瑙及其周边地区儿童再生障碍性贫血的发病率，并结合血液中有机氯水平进行分析，同时审查数据库以探究该疾病与接触杀虫剂之间的关联。
根据既定标准共确定了25例儿童再生障碍性贫血病例，并在为期1年的研究期间纳入研究。使用配备电子捕获检测器的气液色谱仪测定他们血液中的有机氯水平。
发现勒克瑙及其周边地区儿童再生障碍性贫血的年发病率为每百万人口6.8例，高于许多国家（如法国、巴西、英国和美国），但低于瑞典、中国以及一项欧洲 - 以色列合作研究所报告的发病率。再生障碍性贫血患儿血液中的α - 六氯环己烷、γ - 六氯环己烷、δ - 六氯环己烷、总六氯环己烷和p, p' - 滴滴伊水平高于对照组儿童；仅α - 六氯环己烷存在显著差异（P < 0.05）。
尽管这项统计效力有限的初步研究不支持有机氯暴露与儿童再生障碍性贫血风险之间存在任何关联，但鉴于有几例病例是在接触杀虫剂后确诊的，因此不能排除两者之间存在潜在关联。
