Bala Manju, K Menaka, Gupta Anjali
Department of Biochemistry, Pt. B. D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), India.
Department of Obstetrics and Gynaecology, Pt. B. D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), Haryana, India.
EJIFCC. 2017 Oct 10;28(3):196-204. eCollection 2017 Oct.
Polycystic ovary syndrome (PCOS) is a heterogeneous, multisystem endocrinopathy in women of reproductive age manifested with various metabolic disturbances and a wide spectrum of clinical features such as obesity, menstrual abnormalities and hyperandrogenism. Hyperinsulinemia was noted in 50% to 70% of PCOS patients and plays a central role in the development of further complications. The prevalence of obesity in PCOS ranges from 38% to 87%. It has been reported in previous studies that the prevalence of insulin resistance (IR) is higher in obese PCOS women than obesity without PCOS.
To correlate HbA levels with body mass index (BMI) in newly diagnosed polycystic ovary syndrom (PCOS) women.
This case-control study performed at Pt. B. D. Sharma PGIMS, Rohtak includes 30 newly diagnosed PCOS patients and 30 age matched healthy controls of any age. Fasting venous blood samples were obtained for analysis of fasting blood glucose, haemoglobin and HbA after obtaining written consent.
HbA concentration was higher in cases (6.03±0.19%) than in controls (5.35± 0.08%) with p = 0.002. 33.3% were in pre diabetic range (5.7-6.4%), 36.7% in diabetic range (≥6.5%) and 30% in non diabetic range (<5.7%). BMI of cases (26.09±4.2 kg/m) was significantly higher than controls (22.9±3.3 kg/m) with p=0.002. HbA showed positive correlation with BMI (p= 0.001).
In conclusion, BMI is associated with glycemic control in PCOS.
多囊卵巢综合征（PCOS）是一种发生于育龄女性的异质性多系统内分泌病，表现为各种代谢紊乱以及一系列广泛的临床特征，如肥胖、月经异常和高雄激素血症。50%至70%的PCOS患者存在高胰岛素血症，其在进一步并发症的发生中起核心作用。PCOS患者中肥胖的患病率在38%至87%之间。既往研究报道，肥胖的PCOS女性中胰岛素抵抗（IR）的患病率高于无PCOS的肥胖女性。
探讨新诊断的多囊卵巢综合征（PCOS）女性糖化血红蛋白（HbA）水平与体重指数（BMI）之间的关系。
本病例对照研究在罗塔克市Pt. B. D. Sharma研究生医学科学研究所进行，纳入30例新诊断的PCOS患者和30例年龄匹配的各年龄段健康对照。在获得书面同意后，采集空腹静脉血样本用于检测空腹血糖、血红蛋白和HbA。
病例组HbA浓度（6.03±0.19%）高于对照组（5.35±0.08%），p = 0.002。33.3%处于糖尿病前期范围（5.7 - 6.4%），36.7%处于糖尿病范围（≥6.5%），30%处于非糖尿病范围（<5.7%）。病例组BMI（26.09±4.2 kg/m²）显著高于对照组（22.9±3.3 kg/m²），p = 0.002。HbA与BMI呈正相关（p = 0.001）。
总之，BMI与PCOS患者的血糖控制相关。
