Bowmer C J, Collis M G, Yates M S
Department of Pharmacology, University Leeds, UK.
J Pharm Pharmacol. 1988 Oct;40(10):733-5. doi: 10.1111/j.2042-7158.1988.tb07007.x.
The importance of timing and duration of 8-phenyltheophylline (8-PT) administration in determining its beneficial action in glycerol-induced acute renal failure (ARF) was investigated by examining the effects of a single dose of 8-PT given immediately following (0 h) glycerol injection and at 1 and 3 h after glycerol injection. 8-PT when given at 0 h significantly lowered plasma urea and creatinine concentrations and significantly increased inulin clearance when compared both to untreated animals and those that received the vehicle for the drug. By contrast, 8-PT when administered at 1 h afforded no protective effect on renal function and, when injected at 3 h, the only significant effect was lowered plasma creatinine levels when compared to untreated rats; at this latter time it did not lower plasma urea levels or improve inulin clearance. None of the 8-PT injections attenuated the increase in kidney weight associated with ARF or reduced the kidney damage as assessed by histological examination. The results show that a single administration of 8-PT made immediately following glycerol injection can ameliorate the biochemical and functional indices of impaired renal function, but does not produce an improvement in kidney morphology.
通过检测甘油注射后即刻（0小时）、1小时和3小时给予单剂量8-苯基茶碱（8-PT）的效果，研究了8-PT给药时间和持续时间对其在甘油诱导的急性肾衰竭（ARF）中发挥有益作用的重要性。与未治疗的动物以及接受药物载体的动物相比，0小时给予8-PT可显著降低血浆尿素和肌酐浓度，并显著提高菊粉清除率。相比之下，1小时给予8-PT对肾功能无保护作用，3小时注射时，与未治疗的大鼠相比，唯一显著的作用是降低血浆肌酐水平；此时它并未降低血浆尿素水平或改善菊粉清除率。所有8-PT注射均未减轻与ARF相关的肾脏重量增加，也未通过组织学检查减轻肾脏损伤。结果表明，甘油注射后即刻单次给予8-PT可改善肾功能受损的生化和功能指标，但不能改善肾脏形态。
