Baumann P, Perey M, Laurian S, Grasset F, Steck A, Gaillard J M
J Neural Transm Suppl. 1979(15):165-76. doi: 10.1007/978-3-7091-2243-3_15.
The extended theory about a dysfunction of the serotoninergic system in depression and schizophrenia includes the hypothesis of a disturbance in the transport systems of tryptophan and tyrosine from blood to brain. It would be interesting to know if blood cells may be used as a model for the central transport mechanisms of these amino acids. After an oral load, the in vivo distribution of L-tryptophan (50 mg/kg) was studied in the blood plasma, in the different blood cells and its binding to plasma albumin, in six healthy, seven schizophrenic and two depressive subjects. In all the compartments studied, tryptophan reached a peak, 1--2 hours after the load. Before and after the load, the variation of the tryptophan concentration in the erythrocytes was parallel to the plasma free tryptophan, whereas the uptake of this amino acid was higher in leukocytes and thrombocytes than in erythrocytes. However, this model does not show differences between schizophrenic and normal subjects with regard to the transport of tryptophan and tyrosine in these cells.
关于抑郁症和精神分裂症中血清素能系统功能障碍的扩展理论包括色氨酸和酪氨酸从血液到大脑的转运系统受到干扰的假说。了解血细胞是否可用作这些氨基酸中枢转运机制的模型将是很有意思的。在口服负荷后，在六名健康受试者、七名精神分裂症患者和两名抑郁症患者中，研究了L-色氨酸（50mg/kg）在血浆、不同血细胞中的体内分布及其与血浆白蛋白的结合情况。在所有研究的隔室中，色氨酸在负荷后1-2小时达到峰值。负荷前后，红细胞中色氨酸浓度的变化与血浆游离色氨酸平行，而白细胞和血小板中这种氨基酸的摄取高于红细胞。然而，该模型在这些细胞中色氨酸和酪氨酸的转运方面未显示出精神分裂症患者与正常受试者之间的差异。
