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抑郁症患者血小板中色氨酸的积累。

Tryptophan accumulation by blood platelets of depressed patients.

作者信息

Wood K, Swade C, Coppen A

出版信息

J Neural Transm Suppl. 1979(15):161-3. doi: 10.1007/978-3-7091-2243-3_14.

DOI:10.1007/978-3-7091-2243-3_14
PMID:290754
Abstract

The accumulation of tryptophan by blood platelets has been investigated in depressive patients and controls using short incubation times and low substrate concentrations. The accumulation of tryptophan by the platelet is significantly greater in the acutely depressed patients than the control group. The results are discussed with reference to tryptophan transport in depression and also to the regulation of plasma levels of tryptophan.

摘要

利用短孵育时间和低底物浓度,对抑郁症患者和对照组血小板中色氨酸的积累情况进行了研究。急性抑郁症患者血小板中色氨酸的积累显著高于对照组。结合抑郁症中色氨酸的转运以及血浆色氨酸水平的调节对结果进行了讨论。

相似文献

1
Tryptophan accumulation by blood platelets of depressed patients.抑郁症患者血小板中色氨酸的积累。
J Neural Transm Suppl. 1979(15):161-3. doi: 10.1007/978-3-7091-2243-3_14.
2
Platelet 5-hydroxytryptamine accumulation in depressive illness.抑郁症中血小板5-羟色胺的积聚
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Distribution of tryptophan in erythrocytes, leukocytes and thrombocytes, and its binding to plasma albumin.色氨酸在红细胞、白细胞和血小板中的分布及其与血浆白蛋白的结合。
J Neural Transm Suppl. 1979(15):165-76. doi: 10.1007/978-3-7091-2243-3_15.
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Gonadal hormone levels and platelet tryptophan and serotonin concentrations in perimenopausal women with or without depressive symptoms.围绝经期有或无抑郁症状妇女的性腺激素水平与血小板色氨酸和 5-羟色胺浓度。
Gynecol Endocrinol. 2014 Mar;30(3):232-5. doi: 10.3109/09513590.2013.875994. Epub 2014 Jan 23.
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Evidence for a defective platelet L-tryptophan transport in depressed patients.抑郁症患者血小板L-色氨酸转运缺陷的证据。
Int Clin Psychopharmacol. 1993 Summer;8(2):87-93. doi: 10.1097/00004850-199300820-00002.
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Platelet serotonin content and plasma tryptophan in peri- and postmenopausal women: variations with plasma oestrogen levels and depressive symptoms.围绝经期和绝经后女性的血小板血清素含量及血浆色氨酸:随血浆雌激素水平和抑郁症状的变化
Eur J Clin Invest. 1988 Jun;18(3):297-304. doi: 10.1111/j.1365-2362.1988.tb01262.x.
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Platelet serotonin and plasma tryptophan in depressed patients: effect of drug treatment and clinical outcome.抑郁症患者的血小板5-羟色胺和血浆色氨酸:药物治疗效果及临床转归
Neuropsychopharmacology. 1994 May;10(3):207-14. doi: 10.1038/npp.1994.23.
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Peripheral serotonergic markers in acutely suicidal patients. 1. Comparison of serotonergic platelet measures between suicidal individuals, nonsuicidal patients with major depression and healthy subjects.急性自杀患者的外周血清素能标志物。1. 自杀个体、非自杀性重度抑郁症患者与健康受试者之间血清素能血小板指标的比较。
J Neural Transm (Vienna). 2007;114(4):479-87. doi: 10.1007/s00702-006-0555-x. Epub 2006 Sep 21.
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Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior.抑郁症患者血小板5-羟色胺2A受体结合及色氨酸可用性与近期自杀未遂史无关,而与自杀行为特征性的人格特质相关。
J Affect Disord. 2006 Mar;91(1):57-62. doi: 10.1016/j.jad.2005.11.016. Epub 2006 Jan 18.
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Platelet serotonin and plasma tryptophan decreases in endogenous depression. Clinical, therapeutic, and biological correlations.内源性抑郁症患者血小板5-羟色胺及血浆色氨酸水平降低。临床、治疗及生物学相关性研究。
J Affect Disord. 1992 Feb;24(2):55-62. doi: 10.1016/0165-0327(92)90019-3.

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