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更接近有效的缺血性脑卒中干预措施:干细胞的重大承诺。

Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell.

机构信息

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Ahmedabad, Gandhinagar, Gujarat, 382355, India.

Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.

出版信息

Transl Stroke Res. 2018 Aug;9(4):356-374. doi: 10.1007/s12975-017-0580-0. Epub 2017 Oct 26.

Abstract

Stem cell therapy for ischemic stroke has widely been explored. Results from both preclinical and clinical studies have immensely supported the judicious use of stem cells as therapy. These provide an attractive means for preserving and replacing the damaged brain tissues following an ischemic attack. Since the past few years, researchers have used various types of stem cells to replenish insulted neuronal and glial cells in neurological disorders. In the present review, we discuss different types of stem cells employed for the treatment of ischemic stroke and mechanisms and challenges these cells face once introduced into the living system. Further, we also present different ways to maneuver and overcome challenges to translate the advances made at the preclinical level to clinics.

摘要

干细胞疗法在缺血性中风中的应用已得到广泛探索。临床前和临床研究的结果都极大地支持了明智地使用干细胞作为治疗方法。这为在缺血性攻击后保护和替换受损的脑组织提供了一种有吸引力的手段。在过去的几年中,研究人员已经使用各种类型的干细胞来补充神经退行性疾病中受损的神经元和神经胶质细胞。在本综述中,我们讨论了用于治疗缺血性中风的不同类型的干细胞,以及这些细胞进入活体内后所面临的机制和挑战。此外,我们还介绍了不同的方法来应对和克服挑战,将临床前阶段的进展转化为临床实践。

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