CCN2/结缔组织生长因子研究的早期历史：经由hcs24、结缔组织生长因子、生态生成素和再生素通往CCN2的道路。
An early history of CCN2/CTGF research: the road to CCN2 via hcs24, ctgf, ecogenin, and regenerin.
作者信息
Takigawa Masaharu
机构信息
Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Okayama University Dental School/Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, 700-8525, Japan.
出版信息
J Cell Commun Signal. 2018 Mar;12(1):253-264. doi: 10.1007/s12079-017-0414-6. Epub 2017 Oct 26.
Abstract
The principal aim of this historical review is to present the processes by which the different aspects of CCN2/CTGF/Hcs24 were discovered by different groups and how much CCN2/CTGF, by being integrated into CCN family, has contributed to the establishment of the basic concepts regarding the role and functions of this new class of proteins. This review should be particularly useful to new investigators who have recently entered this exciting field of study and also provides a good opportunity to acknowledge the input of those individuals who participated in the development of this scientific field.
摘要
本历史回顾的主要目的是介绍不同研究团队发现CCN2/CTGF/Hcs24各个方面的过程，以及CCN2/CTGF如何通过融入CCN家族，为建立有关这类新蛋白质的作用和功能的基本概念做出贡献。这篇综述对于最近进入这个令人兴奋的研究领域的新研究人员应该特别有用，同时也提供了一个很好的机会来感谢那些参与这一科学领域发展的个人所做出的贡献。
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