Sunagawa Gengo, Karimov Jamshid H, Dessoffy Raymond, Byram Nicole, Grady Patrick, Sinkewich Martin, Naber Jeffrey P, Vincent Douglas, Okano Shinji, Stewart Robert D, Sale Shiva M, Moazami Nader, Fukamachi Kiyotaka
Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH.
Department of Thoracic and Cardiovascular Surgery, Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH.
Artif Organs. 2018 Feb;42(2):231-235. doi: 10.1111/aor.12986. Epub 2017 Oct 27.
The VentriFlo True Pulse Pump (Design Mentor, Inc., Pelham, NH, USA) is the first blood pump designed to mimic human arterial waveforms in a standard oxygenation circuit. Our aim was to demonstrate the feasibility and safety of this pump in preparation for future studies to determine possible clinical advantages. We studied four piglets (41.4-46.2 kg): three with an implanted VentriFlo pulsatile pump and one with the nonpulsatile ROTAFLOW pump (MAQUET Holding B.V. & Co. KG, Rastatt, Germany) as a control. Hemodynamics was monitored during 6-h cardiopulmonary bypass (CPB) support and for 2 h after weaning off CPB. The VentriFlo demonstrated physiologic arterial waveforms with arterial pulse pressure of 24.6 ± 5.7 mm Hg. Pump flows (2.0 ± 0.1 L/min in ROTAFLOW; 1.9 ± 0.1 L/min in VentriFlo) and plasma free hemoglobin levels (27.9 ± 12.5 mg/dL in ROTAFLOW; 28.5 ± 14.2 mg/dL in VentriFlo) were also comparable, but systemic O extraction (as measured by arterial minus venous O saturation) registered slightly higher with the VentriFlo (63.2 ± 6.9%) than the ROTAFLOW (55.4 ± 6.5%). Histological findings showed no evidence of ischemic changes or thromboembolism. This pilot study demonstrated that the VentriFlo system generated pulsatile flow and maintained adequate perfusion of all organs during prolonged CPB.
VentrFlo True Pulse泵（美国新罕布什尔州佩勒姆市的Design Mentor公司）是首款设计用于在标准氧合回路中模拟人体动脉波形的血泵。我们的目的是证明该泵在为未来研究确定可能的临床优势做准备时的可行性和安全性。我们研究了4只仔猪（体重41.4 - 46.2千克）：3只植入了VentrFlo搏动泵，1只植入了非搏动性ROTAFLOW泵（德国拉施塔特的MAQUET Holding B.V. & Co. KG公司）作为对照。在6小时的体外循环（CPB）支持期间以及脱离CPB后2小时监测血流动力学。VentrFlo显示出具有24.6±5.7毫米汞柱动脉脉压的生理性动脉波形。泵流量（ROTAFLOW为2.0±0.1升/分钟；VentrFlo为1.9±0.1升/分钟）和血浆游离血红蛋白水平（ROTAFLOW为27.9±12.5毫克/分升；VentrFlo为28.5±14.2毫克/分升）也具有可比性，但VentrFlo的全身氧摄取（通过动脉减去静脉氧饱和度测量）略高于ROTAFLOW（分别为63.2±6.9%和55.4±6.5%）。组织学检查结果未显示缺血性改变或血栓栓塞的证据。这项初步研究表明，VentrFlo系统在长时间CPB期间产生搏动性血流并维持所有器官的充分灌注。
