Hellenic Reference Center for Alzheimer Disease and Related Syndromes, Alykes, Volos, Greece.
First Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Greece.
Curr Pharm Des. 2017;23(42):6369-6372. doi: 10.2174/1381612823666171024153144.
An archaic surgical procedure, the skull trepanning, was introduced in ancient Greece to treat brain derangement, and endured until the 18th century with the same use. Hippocrates recognized epilepsy as a common entity and categorized it as a brain disorder, removing any divine origin. He proposed that the excess of black bile and mucus is due to the infiltration of air inside the blood circulation (veins). For him it was a hereditary disease that could be cured. Thus, he suggested a non-invasive treatment based on herbal potions, and a surgical treatment by using the most advanced operation of the era, the open brain drilling, known as trepanning, or trephination, setting the beginning of neurosurgery.
一种古老的外科手术，颅骨环锯术，在古希腊被引入以治疗脑紊乱，并一直持续到 18 世纪，用途相同。希波克拉底将癫痫视为一种常见的病症，并将其归类为一种脑部疾病，消除了任何神性起源。他提出，过多的黑胆汁和黏液是由于空气渗透到血液循环（静脉）中。对他来说，这是一种遗传性疾病，可以治愈。因此，他建议采用基于草药药水的非侵入性治疗方法，以及采用当时最先进的手术方法——开颅钻孔，即颅骨环锯术或颅骨钻孔术进行手术治疗，从而开创了神经外科学的先河。
