进化特化的阐述：根瘤菌目中的AbcR小RNA
An account of evolutionary specialization: the AbcR small RNAs in the Rhizobiales.
作者信息
Sheehan Lauren M, Caswell Clayton C
机构信息
Department of Biomedical Sciences and Pathobiology, VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
出版信息
Mol Microbiol. 2018 Jan;107(1):24-33. doi: 10.1111/mmi.13869. Epub 2017 Nov 17.
Abstract
The AbcR small RNAs (sRNAs) are a fascinating example of two highly conserved sRNAs that differ tremendously at the functional level among organisms. From their transcriptional activation to their regulatory capabilities, the AbcR sRNAs exhibit varying characteristics in three well-studied bacteria belonging to the Rhizobiales order: the plant symbiont Sinorhizobium meliloti, the plant pathogen Agrobacterium tumefaciens, and the animal pathogen Brucella abortus. This review outlines the similarities and differences of the AbcR sRNAs between each of these organisms, and discusses reasons as to why this group of sRNAs has diverged in their genetic organization and regulatory functions across species. In the end, this review will shed light on how regulatory systems, although seemingly conserved among bacteria, can vary based on the environmental niche and lifestyle of an organism.
摘要
AbcR小RNA（sRNA）是两个高度保守的sRNA的有趣例子，它们在不同生物体的功能水平上差异巨大。从转录激活到调控能力，AbcR sRNA在属于根瘤菌目的三种经过充分研究的细菌中表现出不同的特征：植物共生菌苜蓿中华根瘤菌、植物病原菌根癌农杆菌和动物病原菌流产布鲁氏菌。本综述概述了这些生物体中AbcR sRNA之间的异同，并讨论了为什么这组sRNA在物种间的基因组织和调控功能上存在差异的原因。最后，本综述将阐明尽管细菌间的调控系统看似保守，但如何根据生物体的环境生态位和生活方式而有所不同。
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